| Title | Bioeffects of Inhaled Nanoplastics on Neurons and Alteration of Animal Behaviors through Deposition in the Brain |
| Authors | Liu, Xiaoyan Zhao, Yingcan Dou, Jiabin Hou, Qinghong Cheng, Jinxiong Jiang, Xingyu |
| Affiliation | Southern Univ Sci & Technol, Shenzhen Key Lab Smart Healthcare Engn, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China Univ Chinese Acad Sci, CAS Ctr Excellence Nanosci, Natl Ctr NanoSci & Technol, Beijing 100190, Peoples R China Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China |
| Keywords | NANOPARTICLES DELIVERY |
| Issue Date | 9-Feb-2022 |
| Publisher | NANO LETTERS |
| Abstract | The potential toxicity of nanoplastics on plants has previously been illustrated, but whether nanoplastics could cause neurotoxicity, especially to higher animals, remains unclear. We now demonstrate that nanoplastics can be deposited in the brain via nasal inhalation, triggering neuron toxicity and altering the animal behavior. Polystyrene nanoparticles (PS-NPs) of PS-COOH and PS-NH2 are used as models for nanoplastics. We designed a microfluidic chip to evaluate the PS-NPs with different concentrations, surface ligands, and sizes to interact with neurons. Smaller PS-NPs can induce more cellular uptake than larger PS NPs. PS-NPs with a size of 80 nm can reach and deposit in the brain of mice via aerosol inhalation. Mice inhaling PS-NPs exhibit fewer activities in comparison to those inhaling water droplets. An obvious neurotoxicity of the nanoplastics could be observed from the results of the inhibition of AChE activities. Our results show the potential significance of the physiochemical properties of organic nanoplastics on depositing in mammalian brains by nasal inhalation. |
| URI | http://hdl.handle.net/20.500.11897/641866 |
| ISSN | 1530-6984 |
| DOI | 10.1021/acs.nanolett.1c04184 |
| Indexed | SCI(E) |
| Appears in Collections: | 前沿交叉学科研究院 |
