| Title | Incidence of and risk factors for liver damage in patients with HIV-1 mono-infection receiving antiretroviral therapy |
| Authors | Huang, Huihuang Song, Bing Gao, Lin Cheng, Juan Mao, Yufeng Zhao, Hua Tu, Bo Huang, Shun Zhang, Jieli Chen, Dianjie Zhao, Peng Jiao, Yan-Mei Jiang, Tianjun |
| Affiliation | Chinese Peoples Liberat Army Gen Hosp, Med Ctr 5, Dept Infect Dis, Beijing, Peoples R China Peking Univ, Sch Basic Med Sci, Dept Microbiol, Hlth Sci Ctr, Beijing, Peoples R China Peking Univ, Sch Basic Med Sci, Infect Dis Ctr, Hlth Sci Ctr, Beijing, Peoples R China Bengbu Med Coll, Bengbu, Peoples R China Chinese Peoples Liberat Army Gen Hosp, Med Ctr 5, Crit Care Unit, Beijing, Peoples R China |
| Keywords | HEPATOTOXICITY INDIVIDUALS HEPATITIS |
| Issue Date | Mar-2022 |
| Publisher | HIV MEDICINE |
| Abstract | Objectives The study aimed to investigate the incidence of and risk factors for liver damage in patients with human immunodeficiency virus type-1 (HIV-1) mono-infection receiving antiretroviral therapy (ART). Methods We retrospectively analyzed the clinical data of patients who were diagnosed with HIV-1 infection and initiated ART from January to December 2017. Among them, 382 patients with HIV-1 mono-infection and normal baseline liver function were included in the analysis. The incidence of liver damage at each follow-up point, and possible risk factors for liver damage were evaluated via COX regression survival analyses. Results The overall incidence of liver damage (grade I-IV) was 27.23% (interquartile range [IQR]: 26.38%-28.72%). Grade I liver damage was most common and accounted for 22.13% of cases (IQR: 21.06%-24.04%), while grade II liver damage accounted for 3.40% of cases (IQR: 3.19%-4.26%). COX regression and survival analyses revealed that baseline body mass index (BMI), alanine aminotransferase (ALT) level, CD4(+) T cell count, HIV-1 viral load, and the antiretroviral regimen were significantly correlated with the occurrence of liver damage. Moreover, baseline ALT levels and HIV-1 viral load were identified as independent risk factors for liver damage in patients with HIV-1 mono-infection. Conclusion Liver damage is common in patients with HIV-1 mono-infection undergoing ART. Patients with risk factors for liver damage should be well-informed before the initiation of ART, and liver function should be closely monitored during ART even in patients with normal liver function before ART. |
| URI | http://hdl.handle.net/20.500.11897/639266 |
| ISSN | 1464-2662 |
| DOI | 10.1111/hiv.13245 |
| Indexed | SCI(E) |
| Appears in Collections: | 基础医学院 |
