| Title | Signal enhancement ratio of CE-MRI: a potential biomarker of survival after hepatic arterial infusion chemotherapy in biliary tract cancers |
| Authors | Zheng, Kanglian Fu, Shijie Leng, Boyu Cui, Yong Yang, Renjie Cao, Guang Xu, Liang Li, Wen-Qing Li, Ying Zhu, Xu Gao, Song Liu, Peng Wang, Xiaodong |
| Affiliation | Peking Univ, Canc Hosp & Inst, Dept Intervent Therapy, Key Lab Carcinogenesis & Translat Res,Minist Educ, 52 Fucheng Rd, Beijing, Peoples R China Hebei North Univ, 11 Zuanshi South Rd, Zhangjiakou, Hebei, Peoples R China Peking Univ, Canc Hosp & Inst, Dept Radiol, Key Lab Carcinogenesis & Translat Res,Minist Educ, 52 Fucheng Rd, Beijing, Peoples R China Peking Univ, Canc Hosp & Inst, Dept Canc Epidemiol, Key Lab Carcinogenesis & Translat Res,Minist Educ, 52 Fucheng Rd, Beijing, Peoples R China |
| Keywords | FORMING CHOLANGIOCARCINOMA TUMOR ANGIOGENESIS GD-DTPA MASS OXALIPLATIN MULTICENTER GEMCITABINE PLACEMENT CATHETER ACID |
| Issue Date | 14-Mar-2022 |
| Publisher | INSIGHTS INTO IMAGING |
| Abstract | Background The association of contrast-enhanced MRI (CE-MRI) and the overall survival (OS) of biliary tract cancers (BTC) is ambiguous. Thus, the aim of this study is to evaluate the value of signal enhancement ratio (SER) and its early change in CE-MRI as biomarkers of survival after hepatic arterial infusion chemotherapy (HAIC) in BTC. Results One hundred and two BTC patients treated via HAIC with 3cir-OFF regimen between January 2011 and June 2020 were enrolled in this retrospective study. The median progression-free survival (PFS) and OS were 9.8 months [range 1.5-83.3 months, 95% confidence interval (CI) 7.789-11.811] and 14.2 months (range 1.8-83.3 months, 95% CI: 11.106-17.294), respectively. The cutoff value of SER before HAIC (SER0) was 1.04, and both median PFS and OS in the SER0 >= 1.04 group were longer than in the SER0 < 1.04 group (median PFS: 10.5 vs. 8.5 months, p = 0.027; median OS: 23.9 vs. 12.3 months, p < 0.001). The median OS in the Delta SER > 0 group was longer than in the Delta SER < 0 group (17.3 versus 12.8 months, p = 0.029 (Delta SER means the change of SER after two cycles of HAIC). Multivariate analysis showed SER0 (p = 0.029) and HAIC treatment cycle (p = 0.002) were independent predictors of longer survival. Conclusions SER in CE-MRI before HAIC (SER0) is a potential biomarker for the prediction of survival after HAIC in advanced BTC. |
| URI | http://hdl.handle.net/20.500.11897/639249 |
| ISSN | 1869-4101 |
| DOI | 10.1186/s13244-022-01188-6 |
| Indexed | SCI(E) |
| Appears in Collections: | 北京肿瘤医院 |
