| Title | Associations between differences in anemia-related blood cell parameters and short-term exposure to ambient particle pollutants in middle-aged and elderly residents in Beijing, China |
| Authors | Gao, Ke Chen, Xi Zhang, Lina Yao, Yuan Chen, Wu Zhang, Hanxiyue Han, Yiqun Xue, Tao Wang, Junxia Lu, Liping Zheng, Mei Qiu, Xinghua Zhu, Tong |
| Affiliation | Peking Univ, Coll Environm Sci & Engn, SKL ESPC, Beijing, Peoples R China Peking Univ, Coll Environm Sci & Engn, BIC ESAT, Beijing, Peoples R China Beijing Univ Technol, Coll Environm & Energy Engn, Key Lab Beijing Reg Air Pollut Control, Beijing, Peoples R China Shenzhen Inst Bldg Res Co Ltd, GRiC, Shenzhen, Peoples R China Shichahai Community Hlth Serv Ctr, Beijing, Peoples R China Imperial Coll London, MRC Ctr Environm & Hlth, Dept Epidemiol & Biostat, London, England Peking Univ, Sch Publ Hlth, Minist Hlth, Dept Epidemiol & Biostat,Key Lab Reprod Hlth,Inst, Beijing, Peoples R China |
| Keywords | PARTICULATE AIR-POLLUTION CARDIOVASCULAR-DISEASE FINE PARTICLES ULTRAFINE INFLAMMATION OUTCOMES BIOMARKERS MORTALITY MARKERS STRESS |
| Issue Date | 10-Apr-2022 |
| Publisher | SCIENCE OF THE TOTAL ENVIRONMENT |
| Abstract | Anemia is a highly prevalent disease among older populations, with multiple adverse health outcomes, and particles exposure is a potential risk factor for anemia. However, evidence on associations of exposure to particles with small size with anemia-related blood cell parameters levels in the elderly is limited, and the underlying mechanisms are unclear. Based on a panel study in Beijing, we found that in 135 elderly participants, mass concentrations of particle with an aerodynamic diameter <= 2.5 mu m (PM2.5), black/elemental carbon (BC/EC, particle size range: 0-2.5 pm), and number concentrations of ultrafine particles (UFPs, particle size range: 5.6-93.1 nm) and accumulated mode particles (Acc, size range: 93.1-560 nm) were significantly associated with levels of red blood cell count (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC). The mean +/- SD for PM2.5 , UFPs, Acc, BC, OC, and EC were 69.7 +/- 61.1 mu g/m(3) , 12.5 +/- 4.3 x 10(3)/cm(3) , 1.6 +/- 1.2 x 10(3)/cm(3) , 3.0 +/- 2.0 mu g/m(3) , 8.7 +/- 6.7 mu g/m(3) , and 2.1 +/- 1.6 mu g/m(3) , respectively. Cotinine (higher than 50 ng/mL) is used as an indicator of smoking exposure. The association between MCHC difference and per interquartile range (IQR) increase in average UFPs concentration 14 d before clinical visits was -0.7% (95% CI: -1.1% to -0.3%). Significant associations of UFPs and Acc exposure with MCHC and MCH levels remain robust after adjustment for other pollutants. Furthermore, 25.2% (95% CI: 7.4% to 64.8%) and 29.8% (95% CI: 5.3% to 214.4%) of the difference in MCHC associated with average UFPs and Acc concentrations 14 d before clinical visits were mediated by the level of tumor necrosis factor alpha (TNF alpha), a biomarker of systemic inflammation. Our findings for the first time provide the evidence that shorttermUFPs and Acc exposure contributed to the damage of anemia-related blood cell in the elderly, and systemic inflammation was a potential internal mediator. (C) 2021 Elsevier B.V. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/639069 |
| ISSN | 0048-9697 |
| DOI | 10.1016/j.scitotenv.2021.151520 |
| Indexed | SCI(E) |
| Appears in Collections: | 环境科学与工程学院 公共卫生学院 |
