| Title | MicroProteins: Dynamic and accurate regulation of protein activity |
| Authors | Wu, Qingqing Zhong, Shangwei Shi, Hui |
| Affiliation | Capital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China Beijing Key Lab Plant Gene Resources & Biotechnol, Beijing 100048, Peoples R China Peking Univ, Sch Life Sci, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China Anhui Agr Univ, Sch Life Sci, Natl Engn Lab Crop Stress Resistance Breeding, Hefei 230036, Peoples R China |
| Keywords | SHADE AVOIDANCE TRANSCRIPTION FACTORS CELL ELONGATION GENOME-WIDE ARABIDOPSIS GENES LOOP IDENTIFICATION NETWORK INACTIVATION |
| Issue Date | Feb-2022 |
| Publisher | JOURNAL OF INTEGRATIVE PLANT BIOLOGY |
| Abstract | Proteins usually assemble oligomers or high-order complexes to increase their efficiency and specificity in biological processes. The dynamic equilibrium of complex formation and disruption imposes reversible regulation of protein function. MicroProteins are small, single-domain proteins that directly bind target protein complexes and disrupt their assembly. Growing evidence shows that microProteins are efficient regulators of protein activity at the post-translational level. In the last few decades, thousands of plant microProteins have been predicted by computational approaches, but only a few have been experimentally validated. Recent studies highlighted the mechanistic working modes of newly-identified microProteins in Arabidopsis and other plant species. Here, we review characterized microProteins, including their biological roles, regulatory targets, and modes of action. In particular, we focus on microProtein-directed allosteric modulation of key components in light signaling pathways, and we summarize the biogenesis and evolutionary trajectory of known microProteins in plants. Understanding the regulatory mechanisms of microProteins is an important step towards potential utilization of microProteins as versatile biotechnological tools in crop bioengineering. |
| URI | http://hdl.handle.net/20.500.11897/638669 |
| ISSN | 1672-9072 |
| DOI | 10.1111/jipb.13229 |
| Indexed | SCI(E) |
| Appears in Collections: | 生命科学学院 |
