| Title | Effects of transgenic Bacillus Thuringiensis maize (2A-7) on the growth and development in rats |
| Authors | Zhang, Xiaoxuan Hou, Chao Liu, Siqi Liu, Rui Yin, Xueqian Liu, Xinran Ma, Huijuan Wen, Jing Zhou, Ruoyu Yin, Ning Jian, Yuanzhi Liu, Shan Wang, Junbo |
| Affiliation | Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China Minist Hlth, Key Lab Food Safety Risk Assessment, China Natl Ctr Food Safety Risk Assessment, Beijing 100021, Peoples R China Beijing Key Lab Food Safety Toxicol Res & Evaluat, Beijing 100191, Peoples R China |
| Keywords | GENETICALLY-MODIFIED FOODS CRY1AB PROTEIN GASTROINTESTINAL CONTENTS EASTERN TOWNSHIPS FETAL EXPOSURE SAFETY NEUROTOXICITY TOXICITY QUEBEC ARIS |
| Issue Date | Dec-2021 |
| Publisher | FOOD AND CHEMICAL TOXICOLOGY |
| Abstract | This study aimed to determine the effects of genetically modified insect-resistant maize (2A-7) on the growth and development in developing rats. Rats were fed a diet formulated with 2A-7 maize and were compared with rats fed a diet formulated with non-transgenic maize (CK group) and rats fed AIN-93G diet (BC group). 2A-7 maize was formulated into diets at ratios of 82.4% (H group) and 20.6% (L group); non-transgenic maize was formulated into diets at a ratio of 82.4%. From the first day of pregnancy, adult rats were divided into four groups and fed with the above four diets, respectively. Weaning on postnatal day 21, the diets of offspring were consistent with their parents. The results showed that body weight, hematology, serum biochemistry, organ weight, organ coefficients and allergenicity of offspring fed with 2A-7 maize were comparable with those in the CK and BC groups. In physiological and behavioral development experiments, there was no statistically significant difference among groups. Although mCry1Ab proteins were detected in organs and serum, no histopathological changes were observed among groups. In conclusion, A-7 maize cause no treatment-related adverse effects on offspring, indicating that 2A-7 maize is safe for developing rats. |
| URI | http://hdl.handle.net/20.500.11897/637633 |
| ISSN | 0278-6915 |
| DOI | 10.1016/j.fct.2021.112694 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 |
