| Title | Identifying the Profile of Helicobacter pylori-Negative Gastric Cancers: A Case-Only Analysis within the Stomach Cancer Pooling (StoP) Project |
| Authors | Morais, Samantha Peleteiro, Barbara Araujo, Natalia Malekzadeh, Reza Ye, Weimin Plymoth, Amelie Tsugane, Shoichiro Hidaka, Akihisa Hamada, Gerson Shigueaki Lopez-Carrillo, Lizbeth Zaridze, David Maximovich, Dmitry Aragones, Nuria Castano-Vinyals, Gemma Pakseresht, Mohammadreza Hernandez-Ramirez, Raul Ulises Lopez-Cervantes, Malaquias Leja, Marcis Gasenko, Evita Pourfarzi, Farhad Zhang, Zuo-Feng Yu, Guo-Pei Derakhshan, Mohammad H. Pelucchi, Claudio Negri, Eva La Vecchia, Carlo Lunet, Nuno |
| Affiliation | Univ Porto, EPIUnit, Inst Saude Publ, Porto, Portugal Lab Invest Integrat & Translac Saude Populac ITR, Porto, Portugal Univ Porto, Fac Med, Dept Ciencias Saude Publ & Forenses & Educ Med, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal Univ Tehran Med Sci, Digest Oncol Res Ctr, Digest Dis Res Inst, Tehran, Iran Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden Natl Canc Ctr, Ctr Publ Hlth Sci, Epidemiol & Prevent Grp, Tokyo, Japan Nikkei Dis Prevent Ctr, Sao Paulo, Brazil Mexico Natl Inst Publ Hlth, Morelos, Mexico Russian NN Blokhin Canc Res Ctr, Dept Epidemiol & Prevent, Moscow, Russia Dept Hlth Madrid, Publ Hlth Div, Epidemiol Sect, Madrid, Spain CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain Barcelona Inst Global Hlth ISGlobal, Barcelona, Spain IMIM Hosp del Mar Med Res Inst, Barcelona, Spain Univ Pompeu Fabra UPF, Barcelona, Spain Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB, Canada Univ Leeds, Ctr Epidemiol & Biostat, Nutr Epidemiol Grp, Leeds, W Yorkshire, England Yale Sch Med, Yale Sch Publ Hlth, Dept Biostat, New Haven, CT USA UNAM, Fac Med, Coyoacan, Mexico Digest Dis Ctr GASTRO, Riga, Latvia Univ Latvia, Inst Clin & Prevent Med, Riga, Latvia Univ Latvia, Fac Med, Riga, Latvia Riga East Univ Hosp, Riga, Latvia Ardabil Univ Med Sci, Digest Dis Res Ctr, Ardebil, Iran UCLA, Dept Epidemiol, Fielding Sch Publ Hlth, Los Angeles, CA USA Jonsson Comprehens Canc Ctr, Los Angeles, CA 90034 USA Peking Univ, Med Informat Ctr, Beijing, Peoples R China Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy |
| Keywords | RISK-FACTORS SOCIOECONOMIC POSITION JAPANESE BRAZILIANS TOBACCO SMOKING POOLED ANALYSES PUBLISHED DATA INFECTION CARCINOGENESIS METAANALYSES CONSUMPTION |
| Issue Date | Jan-2022 |
| Publisher | CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION |
| Abstract | Background: The prevalence of Helicobacter pylori-negative gastric cancer (HpNGC) can be as low as 1%, when infection is assessed using more sensitive tests or considering the presence of gastric atrophy. HpNGC may share a high-risk profile contributing to the occurrence of cancer in the absence of infection. We estimated the proportion of HpNGC, using different criteria to define infection status, and compared HpNGC and positive cases regarding gastric cancer risk factors. Methods: Cases from 12 studies from the Stomach cancer Pooling (StoP) Project providing data on H. pylori infection status determined by serologic test were included. HpNGC was reclassified as positive (eight studies) when cases presented CagA markers (four studies), gastric atrophy (six studies), or advanced stage at diagnosis (three studies), and were compared with positive cases. A two-stage approach (random-effects models) was used to pool study-specific prevalence and adjusted odds ratios (OR). Results: Among non-cardia cases, the pooled prevalence of HpNGC was 22.4% (n = 166/853) and decreased to 7.0% (n = 55) when considering CagA status; estimates for all criteria were 21.8% (n = 276/1,325) and 6.6% (n = 97), respectively. HpNGC had a family history of gastric cancer more often [OR = 2.18; 95% confidence interval (CI), 1.03-4.61] and were current smokers (OR = 2.16; 95% CI, 0.52-9.02). Conclusion: This study found a low prevalence of HpNGC, who are more likely to have a family history of gastric cancer in first-degree relatives. Impact: Our results support that H. pylori infection is present in most non-cardia gastric cancers, and suggest that HpNGC may have distinct patterns of exposure to other risk factors. |
| URI | http://hdl.handle.net/20.500.11897/637303 |
| ISSN | 1055-9965 |
| DOI | 10.1158/1055-9965.EPI-21-0402 |
| Indexed | SCI(E) |
| Appears in Collections: | 医学信息中心 |
