| Title | The association of depressive symptoms with disability among adults in China |
| Authors | Peng, Rui Wang, Yongshi Huang, Yueqin Liu, Zhaorui Xu, Xiangdong Ma, Yanjuan Wang, Limin Zhang, Mei Yan, Yongping Wang, Bo Xiao, Shuiyuan Zhou, Liang Li, Lingjiang Zhang, Yan Ma, Chao Zhang, Tingting Yan, Jie Ding, Hua Yu, Yaqin Kou, Changgui Xu, Xiufeng Lu, Jin Wang, Zhizhong He, Shulan Xu, Yifeng He, Yanling Li, Tao Guo, Wanjun Xu, Guangming Yin, Huifang Du, Xiangdong Wu, Yue Li, Guohua Jia, Fujun Shi, Jianfei Chen, Zheli Zhang, Ning Li, Shengju |
| Affiliation | Peking Univ, Natl Clin Res Ctr Mental Disorders, Peking Univ Hosp 6,Inst Mental Hlth, NHC Key Lab Mental Hlth Peking Univ, Beijing 100191, Peoples R China Fourth Peoples Hosp Urumqi, Urumqi 830002, Peoples R China Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing 100050, Peoples R China Fourth Mil Med Univ, Dept Epidemiol, Xian 710032, Shaanxi, Peoples R China Cent South Univ, Sch Publ Hlth, Dept Social Med & Hlth Management, Changsha 410078, Hunan, Peoples R China Cent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha 410011, Hunan, Peoples R China Peking Univ, Inst Social Sci Survey, Beijing 100871, Peoples R China Jilin Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Changchun 130021, Jilin, Peoples R China Kunming Med Univ, Dept Psychiat, Affiliated Hosp 1, Kunming 650032, Yunnan, Peoples R China Ningxia Med Univ, Sch Publ Hlth & Management, Dept Epidemiol & Hlth Stat, Yinchuan 750004, Ningxia, Peoples R China Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai 200030, Peoples R China Sichuan Univ, Mental Hlth Ctr, West China Hosp, Chengdu 610041, Sichuan, Peoples R China Tianjin Anding Hosp, Tianjin 300222, Peoples R China Suzhou Guangji Hosp, Suzhou 215008, Jiangsu, Peoples R China Nanjing Med Univ, Affiliated Wuxi Mental Hlth Ctr, Wuxi 214151, Jiangsu, Peoples R China Chifeng Anding Hosp, Chifeng 024000, Inner Mongolia, Peoples R China Guangdong Gen Hosp, Guangdong Mental Hlth Inst, Guangzhou 510120, Guangdong, Peoples R China Hangzhou Seventh Peoples Hosp, Dept Psychiat, Hangzhou 310013, Zhejiang, Peoples R China Third Peoples Hosp Huzhou, Huzhou 313000, Zhejiang, Peoples R China Nanjing Med Univ, Nanjing Brain Hosp, Nanjing 210029, Jiangsu, Peoples R China Third Peoples Hosp Qinghai, Xining 810007, Qinghai, Peoples R China |
| Keywords | COMMON MENTAL-DISORDERS HEALTH COMORBIDITY PREVALENCE VERSION |
| Issue Date | 1-Jan-2022 |
| Publisher | JOURNAL OF AFFECTIVE DISORDERS |
| Abstract | Background: The symptoms that patients with major depressive disorder (MDD) experience are the dominant contributing factors to its heavy disease burden. This study sought to identify key symptoms leading to disability in patients with MDD. Methods: Subjects consisted of patients who had a 12-month MDD diagnosis based on the China Mental Health Survey (CMHS). World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) was used to assess the degree of disability. The associations between depressive symptoms and disability were analyzed using a linear regression and logistic regression with a complex sampling design. Results: Of the 32,552 community residents, 655 patients were diagnosed with 12-month MDD. The disability rate due to MDD was 1.06% (95% CI: 0.85%-1.28%) among adults in Chinese community and 50.7% (95% CI: 44.3%-57.1%) among MDD patients. Depression was associated with all functional losses measured by the WHODAS. Feelings of worthlessness in life or inappropriate guilt, and psychomotor agitation or retardation were the key symptoms related to disability. Economic status, co-morbidity of physical diseases or anxiety disorders were correlates of disability scores. Limitations: The disability rate might be underestimated due to the exclusion of MDD patients living in hospitals. The effect of treatments on disability was excluded. Conclusions: Psychological symptoms, not somatic symptoms, contribute to disability in MDD patients. Disability worsens when physical diseases or anxiety disorders are present. More attention could be paid to psychological symptoms, physical diseases, and anxiety disorders in MDD patients with disabilities. |
| URI | http://hdl.handle.net/20.500.11897/634150 |
| ISSN | 0165-0327 |
| DOI | 10.1016/j.jad.2021.09.030 |
| Indexed | SCI(E) SSCI |
| Appears in Collections: | 第六医院 社会科学调查中心 |
