| Title | A Formal [3+3+1] Reaction of Enyne-Methylenecyclopropanes through Au(I)-Catalyzed Enyne Cycloisomerization and Rh(I)-Catalyzed [6+1] Reaction of Vinylspiropentanes and CO |
| Authors | Li, Chen-Long Yang, Yusheng Zhou, Yi Yu, Zhi-Xiang |
| Affiliation | Peking Univ, Coll Chem, Beijing Natl Lab Mol Sci BNLMS, Minist EducmKey Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China |
| Keywords | METAL-CATALYZED CYCLOADDITIONS CYCLOPROPYL BUILDING-BLOCKS ENE-VINYLCYCLOPROPANES BOND ACTIVATION ALKYLIDENECYCLOPROPANES TRANSFORMATIONS THERMOCHEMISTRY HETEROCYCLES ELEMENTS |
| Issue Date | Dec-2021 |
| Publisher | ASIAN JOURNAL OF ORGANIC CHEMISTRY |
| Abstract | A formal [3+3+1] reaction through gold(I)-catalyzed enyne cycloisomerization of enyne-methylenecyclopropanes and rhodium(I)-catalyzed [6+1] reaction of vinylspiropentanes and CO has been developed to synthesize aza-6/7 bicyclic compounds, hexahydrocyclohepta[c]pyridinones. DFT calculations reveal that four steps are involved in the [6+1] cycloaddition of vinylspiropentanes and CO, including oxidative addition of cyclopropane to Rh, beta-C elimination, CO insertion and reductive elimination. |
| URI | http://hdl.handle.net/20.500.11897/632903 |
| ISSN | 2193-5807 |
| DOI | 10.1002/ajoc.202100571 |
| Indexed | SCI(E) |
| Appears in Collections: | å å¦ä¸ å å å·¥ç¨ å¦é ¢ 生物有机与分子工程教育部重点实验室 |
