| Title | Adherence to Healthy Lifestyle and Liver cancer in Chinese: a prospective cohort study of 0.5 million people |
| Authors | Song, Ci Lv, Jun Yu, Chengxiao Zhu, Meng Yu, Canqing Guo, Yu Yang, Ling Chen, Yiping Chen, Zhengming Jiang, Tao Ma, Hongxia Jin, Guangfu Shen, Hongbing Hu, Zhibin Li, Liming |
| Affiliation | Nanjing Med Univ, Sch Publ Hlth, Ctr Global Hlth, China Int Cooperat Ctr Environm & Human Hlth,Dept, Nanjing 211166, Peoples R China Nanjing Med Univ, Collaborat Innovat Ctr Canc Personalized Med, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Nanjing 211166, Peoples R China Peking Univ Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China Peking Univ, Ctr Publ Hlth & Epidem Preparedness & Response, Beijing 100191, Peoples R China Nanjing Med Univ, Gusu Sch, Suzhou Municipal Hosp, Affiliated Suzhou Hosp, Suzhou 215008, Peoples R China Chinese Acad Med Sci, Beijing 100730, Peoples R China Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Oxford, England |
| Keywords | HEPATOCELLULAR-CARCINOMA CARDIOVASCULAR-DISEASE RISK-FACTORS HEPATITIS-B CONSUMPTION ALCOHOL PATTERNS OBESITY FRUIT |
| Issue Date | Dec-2021 |
| Publisher | BRITISH JOURNAL OF CANCER |
| Abstract | Background Little prospective evidence exists about whether a combination of healthy lifestyle factors is related to a considerable reduction of liver cancer risk. Methods Based on the prospective China Kadoorie Biobank (CKB) cohort with a total of 492,640 Chinese adults, we examined the associations of five lifestyle factors with risk of liver cancer. Low-risk lifestyle factors were defined as non-smoking, non-drinking, median or higher level of physical activity, a healthy diet, and waist-to-hip ratio (WHR) < 0.90 for men and Results During a median of 10.12 years of follow-up, 2529 liver cancer events were observed. There was a significant decrease in liver cancer risk with the increasing of the healthy lifestyle index scores (P < 0.001). Participants with a favourable lifestyle (4 or 5 healthy lifestyle factors) had a 43% reduced liver cancer risk compared with those with an unfavourable lifestyle (0 or 1 healthy lifestyle factor) (HR, 0.57 [95% CI, 0.47-0.68]). The cumulative protective effect of a healthy lifestyle on liver cancer appeared to be more dramatic for patients with hepatitis B surface antigen (HBsAg) positive, the individuals at high risk of liver cancer. Conclusions Individuals adhering to a favourable lifestyle was associated with a considerable absolute risk reduction of liver cancer. |
| URI | http://hdl.handle.net/20.500.11897/631302 |
| ISSN | 0007-0920 |
| DOI | 10.1038/s41416-021-01645-x |
| Indexed | SCI(E) |
| Appears in Collections: | 医学部待认领 |
