| Title | GLP-1 and Underlying Beneficial Actions in Alzheimer's Disease, Hypertension, and NASH |
| Authors | Li, Qiu-Xuan Gao, Han Guo, Yue-Xin Wang, Bo-Ya Hua, Rong-xuan Gao, Lei Shang, Hong-Wei Lu, Xin Xu, Jing-Dong |
| Affiliation | Capital Med Univ, Xuanwu Hosp, Clin Med Program 5 3, Beijing, Peoples R China Capital Med Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing, Peoples R China Capital Med Univ, Dept Oral Med, Basic Med Coll, Beijing, Peoples R China Peking Univ, Eight Program Clin Med, Hlth Sci Ctr, Beijing, Peoples R China Capital Med Univ, Dept Biomed Informat, Sch Biomed Engn, Beijing, Peoples R China Capital Med Univ, Sch Basic Med Sci, Morphol Expt Ctr, Beijing, Peoples R China |
| Keywords | GLUCAGON-LIKE PEPTIDE-1 FATTY LIVER-DISEASE DIPEPTIDYL PEPTIDASE-4 INHIBITOR RECEPTOR MESSENGER-RNA MITOCHONDRIAL-FUNCTION GLUCOSE-METABOLISM INSULIN-RESISTANCE HEPATIC STEATOSIS MEMORY IMPAIRMENT GENE-EXPRESSION |
| Issue Date | 6-Sep-2021 |
| Publisher | FRONTIERS IN ENDOCRINOLOGY |
| Abstract | GLP-1 is derived from intestinal L cells, which takes effect through binding to GLP-1R and is inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4). Since its discovery, GLP-1 has emerged as an incretin hormone for its facilitation in insulin release and reduction of insulin resistance (IR). However, GLP-1 possesses broader pharmacological effects including anti-inflammation, neuro-protection, regulating blood pressure (BP), and reducing lipotoxicity. These effects are interconnected to the physiological and pathological processes of Alzheimer's disease (AD), hypertension, and non-alcoholic steatohepatitis (NASH). Currently, the underlying mechanism of these effects is still not fully illustrated and a better understanding of them may help identify promising therapeutic targets of AD, hypertension, and NASH. Therefore, we focus on the biological characteristics of GLP-1, render an overview of the mechanism of GLP-1 effects in diseases, and investigate the potential of GLP-1 analogues for the treatment of related diseases in this review. |
| URI | http://hdl.handle.net/20.500.11897/629338 |
| ISSN | 1664-2392 |
| DOI | 10.3389/fendo.2021.721198 |
| Indexed | SCI(E) |
| Appears in Collections: | 医学部待认领 |
