| Title | Clinical remission of rheumatoid arthritis in a multicenter real-world study in Asia-Pacific region |
| Authors | Sun, Xing Li, Ru Cai, Yueming Al-Herz, Adeeba Lahiri, Manjari Choudhury, Minhaj Rahim Hidayat, Rudy Suryana, Bagus Putu Putra Kaneko, Yuko Fujio, Keishi Van Hung, Nguyen Pandya, Sapan Pang, Leong Khai Katchamart, Wanruchada Sigdel, Keshav Raj Paudyal, Buddhi Narongroeknawin, Pongthorn Chevaisrakul, Parawee Sun, Feng Lu, Yu Ho, Carmen Yeap, Swan Sim Li, Zhanguo |
| Affiliation | Peking Univ, Dept Rheumatol & Immunol, Peoples Hosp, 11 Xizhimen South St, Beijing 100044, Peoples R China Peking Univ, Dept Rheumatol & Immunol, Shenzhen Hosp, Shenzhen, Peoples R China Al Amiri Hosp, Dept Internal Med, Rheumatol Unit, Kuwait, Kuwait Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore Bangabandhu Sheikh Mujib Med Univ, Dept Rheumatol, Dhaka, Bangladesh Univ Indonesia, Cipto Mangunkusumo Natl Hosp, Dept Internal Med, Fac Med, Jakarta, Indonesia Brawijaya Univ, Internal Med Dept, Rheumatol Div, Saiful Anwar Hosp, Malang, Indonesia Keio Univ, Dept Internal Med, Div Rheumatol, Sch Med, Tokyo, Japan Univ Tokyo, Grad Sch Med, Dept Allergy & Rheumatol, Tokyo, Japan Bach Mai Hosp, Dept Rheumatol, Giai Phong Rd, Hanoi, Vietnam Vedanta Inst Med Sci & VS Hosp, Ahmadabad, Gujarat, India Tan Tock Seng Hosp, Dept Rheumatol Allergy & Immunol, Singapore, Singapore Mahidol Univ, Fac Med, Dept Med, Div Rheumatol,Siriraj Hosp, Bangkok, Thailand Patan Acad Hlth Sci, Dept Internal Med, Kathmandu, Nepal Phramongkutklao Hosp, Dept Med, Div Rheumatol, Bangkok, Thailand Coll Med, Bangkok, Thailand Mahidol Univ, Fac Med, Dept Med, Div Allergy Immunol & Rheumatol,Ramathibodi Hosp, Bangkok, Thailand Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 38 Xueyuan Rd, Beijing 100191, Peoples R China Nankai Univ, Sch Math Sci, 94 Weijin Rd, Tianjin 300071, Peoples R China Univ Hong Kong, Dept Med, Div Rheumatol, Hong Kong, Peoples R China Subang Jaya Med Ctr, Dept Med, Subang Jaya, Selangor, Malaysia |
| Keywords | DISEASE-ACTIVITY INDEX CARE VALIDATION THERAPY COUNTS |
| Issue Date | Oct-2021 |
| Publisher | LANCET REGIONAL HEALTH-WESTERN PACIFIC |
| Abstract | Background: Clinical remission is an attainable goal for Rheumatoid Arthritis (RA). However, data on RA remission rates from multinational studies in the Asia-Pacific region are limited. We conducted a cross-sectional multicentric study to evaluate the clinical remission status and the related factors in RA patients in the Asia-Pacific region. Methods: RA patients receiving standard care were enrolled consecutively from 17 sites in 11 countries from APLAR RA SIG group. Data were collected on-site by rheumatologists with a standardized case-report form. Remission was analyzed by different definitions including disease activity score using 28 joints (DAS28) based on ESR and CRP, clinical disease activity index (CDAI), simplified disease activity index (SDAI), Boolean remission definition, and clinical deep remission (CliDR). Logistic regression was used to determine related factors of remission. Findings: A total of 2010 RA patients was included in the study, the overall remission rates were 62.3% (DAS28-CRP), 35.5% (DAS28-ESR), 30.8% (CDAI), 26.5% (SDAI), 24.7% (Boolean), and 17.1% (CliDR), respectively, and varied from countries to countries in the Asia-Pacific region. Biological and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) prescription rate was low (17.9%). Compared to patients in non-remission, patients in remission had higher rates of b/tsDMARDs usage and lower rates of GC usage. The favorable related factors were male sex, younger age, fewer comorbidities, fewer extra-articular manifestations (EAM), and use of b/tsDMARDs, while treatment with GC was negatively related to remission. Interpretation: Remission rates were low and varied in the Asia-Pacific region. Treatment with b/tsDMARDs and less GC usage were related to higher remission rate. There is an unmet need for RA remission in the Asia-Pacific region. (C) 2021 The Authors. Published by Elsevier Ltd. |
| URI | http://hdl.handle.net/20.500.11897/629103 |
| ISSN | 2666-6065 |
| DOI | 10.1016/j.lanwpc.2021.100240 |
| Indexed | ESCI |
| Appears in Collections: | 人民医院 深圳医院 公共卫生学院 |
