| Title | Association of Sodium, Potassium and Sodium-to-Potassium Ratio with Urine Albumin Excretion among the General Chinese Population |
| Authors | Sun, Yuewen Zhang, Puhong Li, Yuan He, Feng J. Wu, Jing Xu, Jianwei Zhang, Xiaochang Li, Xian Song, Jing |
| Affiliation | Peking Univ, Hlth Sci Ctr, George Inst Global Hlth, Beijing 100600, Peoples R China Univ New South Wales, Fac Med, Sydney, NSW 2052, Australia Queen Mary Univ London, Wolfson Inst Prevent Med, Barts & London Sch Med & Dent, London EC1M 6BQ, England Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommunicable Dis Control & Pr, Beijing 100000, Peoples R China Chinese Ctr Dis Control & Prevent, Noncommunicable Dis & Aging Hlth Management Div, Beijing 100000, Peoples R China |
| Keywords | CHRONIC KIDNEY-DISEASE DIETARY-SODIUM RISK PROGRESSION PREVALENCE |
| Issue Date | Oct-2021 |
| Publisher | NUTRIENTS |
| Abstract | Mixed evidence was published regarding the association of sodium, potassium and sodium-to-potassium ratio (Na/K ratio) with renal function impairment. This study was conducted to further explore the relationship between sodium, potassium, NA/K ratio and kidney function in the general adult Chinese population. We performed a cross-sectional analysis using the baseline data from the Action on Salt China (ASC) study. 5185 eligible general adult participants from the baseline investigation of the ASC study were included in this analysis. Sodium, potassium and albumin excretion were examined from 24-h urine collection. Albuminuria was defined as albumin excretion rate (AER) greater than or equal to 30 mg/24-h. Mixed linear regression models, adjusted for confounders, were fitted to analyze the association between sodium, potassium and Na/K ratio, and natural log transformed AER. Mixed effects logistic regression models were performed to analyze the odds ratio of albuminuria at each quintile of sodium, potassium and Na/K ratio. The mean age of the participants was 49.5 & PLUSMN; 12.8 years, and 48.2% were male. The proportion of albuminuria was 7.5%.The adjusted mixed linear models indicated that sodium and Na/K ratio was positively associated with natural log transformed AER (Sodium: beta = 0.069, 95%CI [0.050, 0.087], p < 0.001; Na/K ratio: beta = 0.026, 95%CI [0.012, 0.040], p < 0.001). Mixed effects logistic regression models showed that the odds of albuminuria significantly increased with the quintiles of sodium (p < 0.001) and Na/K ratio (p = 0.001). No significant association was found between potassium and the outcome indicators. Higher sodium intake and higher Na/K ratio are associated with early renal function impairment, while potassium intake was not associated with kidney function measured by albumin excretion. |
| URI | http://hdl.handle.net/20.500.11897/628975 |
| DOI | 10.3390/nu13103456 |
| Indexed | SCI(E) |
| Appears in Collections: | 医学部待认领 |
