| Title | Chitosan/Polyvinyl Alcohol/ Lauramidopropyl Betaine/2D-HOF Mixed Film with Abundant Hydrogen Bonds Acts as High Mechanical Strength Artificial Skin |
| Authors | Ye, Qin Chen, Shu-Han Zhang, Ya Ruan, Bo Zhang, Yi-Jie Zhang, Xin-Ke Jiang, Tao Wang, Xiaoge Ma, Ning Tsai, Fang-Chang |
| Affiliation | Hubei Univ, Minist Educ,Key Lab Green Preparat & Applicat Fun, Collaborat Innovat Ctr Adv Organ Chem Mat Co Cons, Hubei Key Lab Polymer Mat,Sch Mat Sci & Engn, Wuhan 430062, Peoples R China Peking Univ, Coll Chem & Mol Engn, Dept Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China Huanggang Normal Univ, Hubei Collaborat Innovat Ctr Characterist Resourc, Hubei Prov Key Lab Econ Forest Germplasm Improvem, Huanggang 438000, Peoples R China |
| Keywords | DRESSING IN-VITRO SILVER NANOPARTICLES PERFORMANCE FRAMEWORK MEMBRANE SERICIN |
| Issue Date | Oct-2021 |
| Publisher | MACROMOLECULAR BIOSCIENCE |
| Abstract | The mechanical properties of artificial skins are complicated to maintain under ensuring air permeability and antimicrobial. Thus, a series of hydrophilic antimicrobial polymer networks are prepared by crosslinking chitosan and polyvinyl alcohol with the lauramidopropyl betaine and hydrogen bond organic framework (CS/PVA/LPB/2D-HOF). The mechanical performance of the control groups and the complex are systematically evaluated to attain an artificial strength skin. The CS/PVA/LPB/2D-HOF complex exhibits strong mechanical abilities than other control groups. By analyzing the IR spectra and the morphology, the synergistic effect of hydrogen bonds between molecules and cracks significantly improves the mechanical properties of the complex. Its maximum tensile strength can reach 29 MPa, and its maximum load capacity can reach 3700 g. Notably, the composite membrane also performs an excellent antimicrobial activity. In vivo and in vitro experiments show that the hybrid membrane can promote tissue regeneration and wound healing (95%). These results may open up the opportunity for future composite material investigations in the artificial skin and tissue engineering field. |
| URI | http://hdl.handle.net/20.500.11897/626967 |
| ISSN | 1616-5187 |
| DOI | 10.1002/mabi.202100317 |
| Indexed | SCI(E) |
| Appears in Collections: | å å¦ä¸ å å å·¥ç¨ å¦é ¢ |
