| Title | Solid phase diversity-oriented lysine modification of cyclic peptides |
| Authors | Zhao, Rongtong Shi, Xiaodong Shi, Linlin Zhao, Hui Yin, Feng Li, Zigang |
| Affiliation | Peking Univ, Sch Chem Biol & Biotechnol, State Key Lab Chem Oncogen, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China |
| Keywords | PROTEIN-PROTEIN INTERACTION HYDROGEN-BOND SURROGATE CONSTRAINED PEPTIDES STAPLED PEPTIDES HELICAL PEPTIDES TARGET MACROCYCLIZATION STRATEGY LINKERS DESIGN |
| Issue Date | Oct-2021 |
| Publisher | JOURNAL OF PEPTIDE SCIENCE |
| Abstract | Herein, we report a novel strategy for diversity-oriented lysine modification of cyclic peptides based on the orthogonal alkylation of the lysine residues. All steps can be achieved in the solid phase with satisfying conversions. Notably, we demonstrated that the tether modification could help to improve the cellular uptake of peptides. |
| URI | http://hdl.handle.net/20.500.11897/626893 |
| ISSN | 1075-2617 |
| DOI | 10.1002/psc.3373 |
| Indexed | SCI(E) |
| Appears in Collections: | 化学生物学与生物技术学院 å å¦ä¸ å å å·¥ç¨ å¦é ¢ |
