| Title | Tuberculosis recurrence over a 7-year follow-up period in successfully treated patients in a routine program setting in China: a prospective longitudinal study |
| Authors | Lin, Yan Lin, Haoxiang Xiao, Lixin Chen, Yongming Meng, Xu Zeng, Xianglin Chang, Chun Brigden, Grania |
| Affiliation | Int Union TB & Lung Dis, Paris, France Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, Hlth Sci Ctr, Beijing, Peoples R China Xingguo Cty TB Dispensary, Xingguo, Peoples R China Ganzhou City Ctr Dis Control & Prevent, Ganzhou, Peoples R China Ningdu Cty TB Dispensary, Ningdu, Peoples R China |
| Keywords | SMOKING INCREASES RISK-FACTORS RELAPSE REINFECTION |
| Issue Date | Sep-2021 |
| Publisher | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES |
| Abstract | Objectives: To determine tuberculosis (TB) recurrence in previously successfully treated patients in a routine program setting and baseline characteristics associated with TB recurrence. Methods: A prospective longitudinal study in Jiangxi Province, China. Patients, >= 14 years old, were consecutively registered and were followed up for seven years to assess TB recurrence against a patients' individual baseline data that had been entered into a database at TB registration. Results: There were 800 TB patients registered at baseline, and 634 (79.2%) of them completed antiTB treatments. Fifty-nine (9.3%) died, and 21 (3.3%) were lost to follow-up over the follow-up period. There were 96 patients with recurrent episodes (total incidence 15.2% or annual incidence 2,200/100,000). Of the recurrent cases, 53 (55.2%) happened within 2-year after completion of anti-TB treatments. After controlling confounding factors, the risk of TB recurrence was significantly higher in the age range 34-73 years (P<0.01) and current smokers (P<0.01). Conclusions: Overall recurrence rate among previously treated TB patients was much higher than the initial incidence in the same population (61-98/100,000) and settings with similar TB incidence. TB programs should consider closer monitoring of these patients for early detection of recurrence. Particular attention should be given to those between 34-73 years and those who use tobacco products. (C) 2021 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. |
| URI | http://hdl.handle.net/20.500.11897/626715 |
| ISSN | 1201-9712 |
| DOI | 10.1016/j.ijid.2021.07.057 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 |
