| Title | The Alteration of Brain Interstitial Fluid Drainage with Myelination Development |
| Authors | Wang, Rui Han, Hongbin Shi, Kuangyu Alberts, Ian Leigh Rominger, Axel Yang, Chenlong Yan, Junhao Cui, Dehua Peng, Yun He, Qingyuan Gao, Yajuan Lian, Jingge Yang, Shuangfeng Liu, Huipo Yang, Jun Wong, Chaolan Wei, Xunbin Yin, Feng Jia, Yanxing Tong, Huaiyu Liu, Bo Lei, Jianbo |
| Affiliation | Peking Univ Third Hosp, Dept Radiol, Beijing, Peoples R China Beijing Key Lab Magnet Resonance Imaging Device &, Beijing, Peoples R China Peking Univ, Inst Med Technol, Hlth Sci Ctr, Beijing, Peoples R China Univ Bern, Dept Nucl Med, Bern, Switzerland Tech Univ Munich, Dept Informat, Garching, Germany Peking Univ Third Hosp, Dept Neurosurg, Beijing, Peoples R China Capital Med Univ, Beijing Childrens Hosp, Dept Radiol, Natl Ctr Childrens Hlth, Beijing, Peoples R China Peking Univ, Sch Pharmaceut Sci, Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China Peking Univ, Biomed Engn Dept, Beijing, Peoples R China Aerosp Ctr Hosp, Dept Neurosurg, Beijing, Peoples R China Peoples Liberat Army Gen Hosp, Dept Neurosurg, Beijing, Peoples R China Inst Appl Phys & Computat Math, Beijing, Peoples R China |
| Keywords | EXTRACELLULAR-SPACE HUMANS AGE T-MAZE RAT DIFFUSION MATURATION MECHANISM |
| Issue Date | Oct-2021 |
| Publisher | AGING AND DISEASE |
| Abstract | The integrity of myelination is crucial for maintaining brain interstitial fluid (ISF) drainage in adults; however, the mechanism of ISF drainage with immature myelin in the developing brain remains unknown. In the present study, the ISF drainage from the caudate nucleus (Cn) to the ipsilateral cortex was studied at different developmental stages of the rat brain (P 10, 20, 30, 40, 60, 80, 10-80). The results show that the traced ISF drained to the cortex from Cn and to the thalamus in an opposite direction before P30. From P40, we found impeded drainage to the thalamus due to myelin maturation. This altered drainage was accompanied by enhanced cognitive and social functions, which were consistent with those in the adult rats. A significant difference in diffusion parameters was also demonstrated between the extracellular space (ECS) before and after P30. The present study revealed the alteration of ISF drainage regulated by myelin at different stages during development, indicating that a regional ISF homeostasis may be essential for mature psychological and cognitive functions. |
| URI | http://hdl.handle.net/20.500.11897/626699 |
| ISSN | 2152-5250 |
| DOI | 10.14336/AD.2021.0305 |
| Indexed | SCI(E) |
| Appears in Collections: | 第三医院 药学院 天然药物与仿生药物国家重点实验室 |
