| Title | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension (CHESS1802): An International Multicenter Study |
| Authors | Liu, Yanna Tang, Tianyu Ormeci, Necati Huang, Yifei Wang, Jitao Li, Xiaoguo Li, Zhiwei An, Weimin Liu, Dengxiang Zhang, Chunqing Liu, Changchun Liu, Jinqiang Liu, Chuan Wang, Guangchuan Mosconi, Cristina Cappelli, Alberta Bruno, Antonio Akcalar, Seray Celebioglu, Emrecan Ustuner, Evren Bilgic, Sadik Ellik, Zeynep Omer Asi, Ozgun Li, Li Zhang, Haijun Kang, Ning Xu, Dan He, Ruiling Wang, Yan Bu, Yang Gu, Ye Ju, Shenghong Golfieri, Rita Qi, Xiaolong |
| Affiliation | First Hosp Lanzhou Univ, Inst Portal Hypertens, CHESS Ctr, 1 Donggang West Rd, Lanzhou, Gansu, Peoples R China Sixth Peoples Hosp Shenyang, CHESS Ctr, Shenyang, Liaoning, Peoples R China Southern Med Univ, Nanfang Hosp, Dept Infect Dis, Guangzhou, Guangdong, Peoples R China Peking Univ, Sch Basic Med Sci, Dept Microbiol, Hlth Sci Ctr, Beijing, Peoples R China Peking Univ, Sch Basic Med Sci, Infect Dis Ctr, Hlth Sci Ctr, Beijing, Peoples R China Southeast Univ, Sch Med, Zhongda Hosp, Dept Radiol, Nanjing, Jiangsu, Peoples R China Istanbul Hlth & Technol Univ, Zytinburnu Istanbul, Turkey Xingtai Peoples Hosp, CHESS Working Party, Xingtai, Hebei, Peoples R China Third Peoples Hosp Shenzhen, Dept Hepatobiliary Surg, Shenzhen, Guangdong, Peoples R China Peoples Liberat Army Gen Hosp, Med Ctr 5, Dept Radiol, Beijing, Peoples R China Shandong Univ, Dept Gastroenterol, Shandong Prov Hosp, Jinan, Shandong, Peoples R China Univ Bologna, Dept Radiol, IRCCS Azienda Osped Univ Bologna, Bologna, Italy Ankara Univ, Dept Radiol, Sch Med, Ankara, Turkey Ankara Univ, Dept Gastroenterol, Sch Med, Ankara, Turkey Peoples Hosp Ningxia Hui Autonomous Reg, Dept Hepatobiliary Surg, Yinchuan, Ningxia, Peoples R China |
| Keywords | SURFACE NODULARITY QUANTIFICATION ACCURATE MARKER CIRRHOSIS FIBROSIS DIAGNOSIS BIOMARKER INDEX CT |
| Issue Date | Sep-2021 |
| Publisher | JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY |
| Abstract | Background and Aims: This study aimed to determine the performance of the non-invasive score using noncontrast-enhanced MRI (CHESS-DIS score) for detecting portal hy-pertension in cirrhosis. Methods: In this international multi-center, diagnostic study (ClinicalTrials.gov, NCT03766880), patients with cirrhosis who had hepatic venous pressure gradient (HVPG) measurement and noncontrast-enhanced MRI were prospectively recruited from five university hos-pitals in China (n=4) and Turkey (n=1) between December 2018 and April 2019. A cohort of patients was retrospec-tively recruited from a university hospital in Italy between March 2015 and November 2017. After segmentation of the liver on fat-suppressed T1-weighted MRI maps, CHESS-DIS score was calculated automatically by an in-house devel-oped code based on the quantification of liver surface nodu-larity. Results: A total of 149 patients were included, of which 124 were from four Chinese hospitals (training co-hort) and 25 were from two international hospitals (vali-dation cohort). A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36 (p<0.0001) and 0.55 (p<0.01) for the training and validation cohorts, respectively. The area under the receiver operating characteristic curve of CHESS-DIS score in detec-tion of clinically significant portal hypertension (CSPH) was 0.81 and 0.9 in the training and validation cohorts, respec-tively. The intraclass correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and |
| URI | http://hdl.handle.net/20.500.11897/626294 |
| ISSN | 2225-0719 |
| DOI | 10.14218/JCTH.2021.00177 |
| Indexed | SCI(E) |
| Appears in Collections: | 基础医学院 |
