| Title | Establishment of epidemiological cut-off values for cefoselis, a new fourth-generation cephalosporin, against Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Proteus mirabilis and Pseudomonas aeruginosa |
| Authors | Li, Xue Jia, Peiyao Zhu, Ying Xu, Yingchun Yu, Yunsong Lv, Yuan Wang, Minggui Sun, Ziyong Lin, Jie Li, Yun Zheng, Bo Hu, Fupin Guo, Yan Chen, Zhongju Li, Haixia Zhang, Ge Zhang, Jingjia Kang, Wei Duan, Simeng Wang, Tong Jing, Ran Yang, Qiwen |
| Affiliation | Chinese Acad Med Sci, Dept Clin Lab, State Key Lab Complex Severe & Rare Dis, Peking Union Med Coll Hosp,Peking Union Med Coll, Beijing 100730, Peoples R China Capital Med Univ, Beijing Anzhen Hosp, Dept Clin Lab, Beijing 100029, Peoples R China Chinese Acad Med Sci, Peking Union Med Coll, Grad Sch, Beijing, Peoples R China Zhejiang Univ, Dept Clin Infect Dis, Sir Run Run Shaw Hosp, Hangzhou, Peoples R China Peking Univ, Inst Clin Pharmacol, Beijing, Peoples R China Fudan Univ, Huashan Hosp, Shanghai, Peoples R China Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan, Peoples R China Peking Univ, Dept Clin Lab, Hosp 1, Beijing, Peoples R China Peking Union Med Coll Hosp, 1 Shuaifuyuan Wangfujing, Beijing, Peoples R China |
| Keywords | IN-VITRO ACTIVITY BROAD-SPECTRUM CEPHALOSPORIN ANTIBACTERIAL ACTIVITY FK037 CEFEPIME PHARMACOKINETICS SUSCEPTIBILITY FK-037 |
| Issue Date | Oct-2021 |
| Publisher | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY |
| Abstract | Objectives: To establish the epidemiological cut-off values (ECOFFs) for cefoselis against Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Proteus mirabilis and Pseudomonas aeruginosa. Methods: We collected 2288 non-repetitive clinical isolates from five laboratories throughout four cities in China. The cefoselis MICs and inhibition zone diameters for all isolates were established using the broth microdilution method and the disc diffusion method following EUCAST guidelines. MIC ECOFFs were determined by visual estimation and ECOFFinder software. Zone diameter ECOFFs were set if a high correlation of MICs and inhibition zone diameters was found by Pearson correlation. Zone diameter ECOFFs were finally determined by the visual estimate method. Results: MICs of cefoselis were distributed from 0.008 to >256mg/L for the four Enterobacterales species and from 0.25 to >256mg/L for P. aeruginosa. MIC ECOFFs were 0.125mg/L for E. coli, K. pneumoniae and P. mirabilis, 0.25mg/L for E. cloacae and 32mg/L for P. aeruginosa. A high correlation of MICs and zone diameters was observed for all Enterobacterales (vertical bar r vertical bar>0.8, P<0.001) and a relatively high correlation was found for P. aeruginosa (vertical bar r vertical bar=0.71, P<0.001). The zone diameter ECOFF was 24mm for E. cloacae, E. coli and K. pneumoniae, 26mm for P. mirabilis and 21mm for P. aeruginosa. Conclusions: We determined MIC and zone diameter ECOFFs for cefoselis against four Enterobacterales species and P. aeruginosa. The establishment of ECOFFs for cefoselis provides clinicians with helpful guidance to differentiate WT and non-WT pathogens. |
| URI | http://hdl.handle.net/20.500.11897/626211 |
| ISSN | 0305-7453 |
| DOI | 10.1093/jac/dkab216 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 |
