| Title | Microglia modulation with 1070-nm light attenuates A beta burden and cognitive impairment in Alzheimer's disease mouse model |
| Authors | Tao, Lechan Liu, Qi Zhang, Fuli Fu, Yuting Zhu, Xi Weng, Xiaofu Han, Hongbin Huang, Yong Suo, Yuanzhen Chen, Liang Gao, Xiaoling Wei, Xunbin |
| Affiliation | Shanghai Jiao Tong Univ, State Key Lab Oncogenes & Related Genes, Shanghai Canc Inst, Med X Res Inst, Shanghai 200030, Peoples R China Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200030, Peoples R China Peking Univ, Inst Med Technol, Hlth Sci Ctr, Beijing 100191, Peoples R China Peking Univ Third Hosp, Dept Radiol, Beijing 100191, Peoples R China Key Lab Magnet Resonance Imaging Device & Tech, Beijing 100191, Peoples R China Zhejiang Brainhlth Med Technol Co Ltd, Hangzhou 314400, Peoples R China Peking Univ, Biomed Pioneering Innovat Ctr, Beijing 100871, Peoples R China Peking Univ, Sch Life Sci, Beijing 100871, Peoples R China Fudan Univ, Huashan Hosp, Shanghai Med Coll, Dept Neurosurg, Shanghai 200040, Peoples R China Huashan Hosp, Tianqiao & Chrissy Chen Inst Clin Translat Res, Shanghai 200040, Peoples R China Shanghai Jiao Tong Univ, Shanghai Univ Collaborat Innovat Ctr Translat Med, Dept Pharmacol & Chem Biol, State Key Lab Oncogenes & Related Genes,Sch Med, Shanghai 200025, Peoples R China Peking Univ, Biomed Engn Dept, Beijing 100081, Peoples R China Peking Univ, Canc Hosp & Inst, Minist Educ Beijing, Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China |
| Keywords | POWER LASER IRRADIATION BRAIN-INJURY PHOTOBIOMODULATION THERAPY CELLS NM PHAGOCYTOSIS ACTIVATION MECHANISMS RESPONSES |
| Issue Date | 8-Sep-2021 |
| Publisher | LIGHT-SCIENCE & APPLICATIONS |
| Abstract | Photobiomodulation, by utilizing low-power light in the visible and near-infrared spectra to trigger biological responses in cells and tissues, has been considered as a possible therapeutic strategy for Alzheimer's disease (AD), while its specific mechanisms have remained elusive. Here, we demonstrate that cognitive and memory impairment in an AD mouse model can be ameliorated by 1070-nm light via reducing cerebral beta-amyloid (A beta) burden, the hallmark of AD. The glial cells, including microglia and astrocytes, play important roles in A beta clearance. Our results show that 1070-nm light pulsed at 10 Hz triggers microglia rather than astrocyte responses in AD mice. The 1070-nm light-induced microglia responses with alteration in morphology and increased colocalization with A beta are sufficient to reduce A beta load in AD mice. Moreover, 1070-nm light pulsed at 10 Hz can reduce perivascular microglia and promote angiogenesis to further enhance A beta clearance. Our study confirms the important roles of microglia and cerebral vessels in the use of 1070-nm light for the treatment of AD mice and provides a framework for developing a novel therapeutic approach for AD. |
| URI | http://hdl.handle.net/20.500.11897/624512 |
| ISSN | 2047-7538 |
| DOI | 10.1038/s41377-021-00617-3 |
| Indexed | EI SCI(E) |
| Appears in Collections: | 第三医院 生命科学学院 北京肿瘤医院 |
