| Title | Acute miliary tuberculosis in pregnancy after in vitro fertilization and embryo transfer: a report of seven cases |
| Authors | Gai, Xiaoyan Chi, Hongbin Cao, Wenli Zeng, Lin Chen, Lixue Zhang, Weixia Song, Donghong Wang, Ying Liu, Ping Li, Rong Sun, Yongchang |
| Affiliation | Peking Univ Third Hosp, Dept Resp & Crit Care Med, 49 N Garden Rd, Beijing 100191, Peoples R China Peking Univ Third Hosp, Dept Obstet & Gynecol, Ctr Reprod Med, 49 N Garden Rd, Beijing 100191, Peoples R China Beijing Geriatr Hosp, TB Dept, Beijing 102699, Peoples R China Peking Univ Third Hosp, Clin Epidemiol Res Ctr, Beijing 100191, Peoples R China Natl Clin Res Ctr Obstet & Gynecol, Beijing 100191, Peoples R China Peking Univ, Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing 100191, Peoples R China |
| Keywords | INFERTILE WOMEN GLOBAL BURDEN PERSPECTIVES DIAGNOSIS |
| Issue Date | 6-Sep-2021 |
| Publisher | BMC INFECTIOUS DISEASES |
| Abstract | Background While miliary tuberculosis (TB) in pregnancy is rare after in vitro fertilization and embryo transfer (IVF-ET), it poses a serious threat to the health of pregnant women and their fetuses. The present study aimed to describe the clinical features of miliary TB and pregnancy outcomes of patients after IVF-ET. Methods Data of infertile patients who received IVF-ET at Peking University Third Hospital between January 2012 and December 2017 were retrospectively analyzed. Patients who developed miliary TB during pregnancy were identified, and clinical characteristics of miliary TB were described. Results Out of 62,755 infertile women enrolled, 7137 (11.4 %) showed signs of prior pulmonary TB on chest X-ray (CXR). Among the 15,136 women (mean age: 33.2 +/- 5.0 years) who successfully achieved clinical pregnancy, seven patients aged 28-35 years had miliary TB during pregnancy, with two patients having a complication of TB meningitis. All these patients presented with fever. Notably, old TB lesions were detected on CXR in six patients before IVF-ET; nevertheless, no anti-TB therapy was administered. Furthermore, salpingography revealed oviduct obstruction in all patients (7/7). Patients received anti-TB therapy following a diagnosis of miliary TB and were clinically cured. However, pregnancy was terminated due to spontaneous (4/7) and induced (3/7) abortion. Conclusions TB reactivation, mostly as miliary TB and TB meningitis, is severe in pregnant women after IVF-ET and deleterious to pregnancy outcomes. Signs of prior TB on CXR may be risk factors for TB reactivation during pregnancy. |
| URI | http://hdl.handle.net/20.500.11897/624390 |
| DOI | 10.1186/s12879-021-06564-z |
| Indexed | SCI(E) |
| Appears in Collections: | 第三医院 |
