| Title | Benign prostatic hyperplasia and cardiovascular risk: a prospective study among Chinese men |
| Authors | Wang, Xiaowen Su, Yang Yang, Chao Hu, Yonghua Dong, Jia-Yi |
| Affiliation | Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hlth Sci Ctr, Beijing 100191, Peoples R China Osaka Univ, Dept Social Med, Publ Hlth, Grad Sch Med, Osaka 5650871, Japan Zhengzhou Univ, Dept Urol, Affiliated Hosp 1, Zhengzhou 450002, Peoples R China Peking Univ First Hosp, Peking Univ, Dept Med, Renal Div,Inst Nephrol, Beijing 100034, Peoples R China |
| Keywords | URINARY-TRACT SYMPTOMS DISEASE ASSOCIATION EPIDEMIOLOGY POPULATION |
| Issue Date | Aug-2021 |
| Publisher | WORLD JOURNAL OF UROLOGY |
| Abstract | Purpose To examine the prospective association of BPH with subsequent risk of CVD, including heart disease and stroke. Methods We used data from China Health and Retirement Longitudinal Study of 5242 Chinese men aged 45 years or older. During a follow-up of 7 years, we identified 613 cases of non-fatal CVD, including 417 heart diseases and 254 strokes. Cox proportional hazards models yielded hazard ratios (HRs) relating BPH to CVD, heart disease, and stroke incidence. Results Overall, 8.1% of men reported a history of BPH diagnosed by physicians at baseline. As compared with men without a history of BPH, those reporting a history of BPH had an increased risk of developing CVD (multivariable-adjusted HR = 1.43 [1.12, 1.83], heart disease (1.35 [1.00, 1.83]), and stroke (1.50 [1.03, 2.19]). The subgroup analysis by age at baseline (< 60 vs. >= 60 years) showed that the associations appeared to be evident among men < 60 years, particularly for CVD (1.82 [1.24, 2.69]) and heart disease (1.72 [1.06, 2.79]). However, interaction tests suggested the associations were not significantly modified by age (P for interaction > 0.10 for all outcomes). Conclusion In Chinese men, BPH was associated with higher risks of CVD, heart disease and stroke, particularly among men aged < 60 years. |
| URI | http://hdl.handle.net/20.500.11897/623874 |
| ISSN | 0724-4983 |
| DOI | 10.1007/s00345-021-03817-z |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 第一医院 |
