| Title | Efficacy of periodontal minimally invasive surgery with and without regenerative materials for treatment of intrabony defect: a randomized clinical trial |
| Authors | Liu, Bei Ouyang, Xiangying Kang, Jun Zhou, Shuangying Suo, Chao Xu, Lingqiao Liu, Jianru Liu, Wenyi |
| Affiliation | Peking Univ, Sch & Hosp Stomatol, Dept Periodontol, 22 Zhongguancun South Ave, Beijing 100081, Peoples R China Natl Clin Res Ctr Oral Dis, 22 Zhongguancun South Ave, Beijing 100081, Peoples R China Natl Engn Lab Digital & Mat Technol Stomatol, 22 Zhongguancun South Ave, Beijing 100081, Peoples R China Beijing Key Lab Digital Stomatol, 22 Zhongguancun South Ave, Beijing 100081, Peoples R China |
| Keywords | GUIDED TISSUE REGENERATION MICROSURGICAL ACCESS FLAP MESENCHYMAL STEM-CELLS SURGICAL TECHNIQUE BONY DEFECTS HISTOLOGIC EVALUATION INFRABONY DEFECTS OUTCOMES LIGAMENT RECRUITMENT |
| Issue Date | Aug-2021 |
| Publisher | CLINICAL ORAL INVESTIGATIONS |
| Abstract | Objectives The minimally invasive surgical technique was modified in suture (MISTms) in this study. The trial was to determine the efficacy of MISTms with and without regenerative materials for the treatment of intrabony defect and to identify factors influencing 1-year clinical attachment level (CAL) gain. Methods Thirty-six patients with interdental intrabony defects were randomly assigned to MISTms (MISTms alone, 18) or MISTms plus deproteinized bovine bone mineral and collagen membrane (MISTms combined, 18). Wound healing was evaluated by early healing index (EHI) at 1, 2, 3, and 6 weeks. Probing depth (PD), CAL, gingival recession, radiographic defect depth, and distance from the base of defect to the cementoenamel junction were recorded at baseline and 1 year postoperatively. A one-year composite outcome measure based on the combination of CAL gain and post-surgery PD was evaluated. Factors influencing 1-year CAL gain were analyzed. Results Fifteen patients in MISTms-alone and 16 in the MISTms-combined group finished the study. The MISTms-alone group showed significantly better wound healing at 1 week. CAL significantly gained in the MISTms-alone and MISTms-combined group, with 2.53 +/- 1.80 mm and 2.00 +/- 1.38 mm respectively. The radiographic bone gain was 3.00 +/- 1.56 mm and 3.85 +/- 1.69 mm respectively. However, there were no significant differences between the two groups about 1-year outcomes. Lower EHI (optimal wound healing) and more baseline CAL positively influenced 1-year CAL gain. Conclusions MISTms is an effective treatment for intrabony defects. The regenerative materials do not show an additional effect on 1-year outcomes. Early wound healing and baseline CAL are factors influencing 1-year CAL gain. |
| URI | http://hdl.handle.net/20.500.11897/623707 |
| ISSN | 1432-6981 |
| DOI | 10.1007/s00784-021-04134-w |
| Indexed | SCI(E) |
| Appears in Collections: | 口腔医院 |
