| Title | Association of depressive symptoms with the progression of carotid intima-media thickness in a community-based cohort in Beijing, China |
| Authors | Liu, Mengyuan Jia, Jia Fan, Fangfang Sun, Pengfei Wu, Zhongli Jiang, Yimeng He, Danmei Liu, Bo Yang, Ying Zhang, Yan |
| Affiliation | Peking Univ First Hosp, Dept Cardiol, Beijing, Peoples R China Peking Univ First Hosp, Inst Cardiovasc Dis, Beijing, Peoples R China Peking Univ First Hosp, Dept Biostat, Beijing, Peoples R China |
| Keywords | CARDIOVASCULAR RISK ATHEROSCLEROSIS DISEASE PLAQUE POPULATION PREVALENCE EVENTS ADULTS ART |
| Issue Date | 2021 |
| Publisher | BMJ OPEN |
| Abstract | Objectives To determine the relationship between depressive symptoms and progression of carotid intima-media thickness (cIMT) in a Beijing community-based population. Design Prospective cohort study between 2014 and 2018. Setting Dwellers without cardiovascular disease, hypertension or diabetes from a Beijing community. Participants 3849 Chinese community-dwelling individuals who underwent baseline screening for depressive symptoms were invited to participate in the study in 2014 and follow-up visit in 2018. Among them, 2124 participants completed carotid ultrasound examination both at baseline and a follow-up visit. After further excluding patients with a history of stroke, myocardial infarction or lower extremity arterial stenosis and those with a diagnosis of hypertension or diabetes and ankle-brachial index <= 0.9 at baseline, 1011 eligible participants were finally included. Primary outcome measure The rate of mean cIMT change. Results Over a median follow-up period of 4.40 years, the overall rate of mean cIMT change was 2.23% (-5.64% to 9.51%). After adjustment for 13 covariates, there was an increase of 2.36% (beta=2.36, 95% CI: 0.37 to 4.36, p=0.020) for the rates of mean cIMT change in the depressive group compared with the control group. Furthermore, this association was modified by drinking status (beta=3.22, 95% CI: 1.25 to 5.19, P-interaction=0.006). Conclusion Depressive symptoms were independently associated with progression of mean cIMT in a community-based cohort in Beijing, China. Furthermore, this relationship was modified by drinking status. |
| URI | http://hdl.handle.net/20.500.11897/623694 |
| ISSN | 2044-6055 |
| DOI | 10.1136/bmjopen-2021-050254 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 |
