| Title | Metagenomics analysis revealing the occurrence of antibiotic resistome in salt lakes |
| Authors | Liang, Hebin Wang, Fan Mu, Rong Huang, Jin Zhao, Renxin Li, Xiaoyan Yu, Ke Li, Bing |
| Affiliation | Tsinghua Univ, Tsinghua Shenzhen Int Grad Sch, Guangdong Prov Engn Res Ctr Urban Water Recycling, Shenzhen 518055, Peoples R China Sun Yat Sen Univ, Southern Marine Sci & Engn Guangdong Lab Zhuhai, Sch Atmospher Sci, Zhuhai 519082, Peoples R China Minist Educ, Key Lab Trop Atmosphere Ocean Syst, Zhuhai 519082, Peoples R China Peking Univ, Shenzhen Grad Sch, Sch Environm & Energy, Shenzhen 518055, Peoples R China Tsinghua Univ, Tsinghua Berkeley Shenzhen Inst, Shenzhen Environm Sci & New Energy Lab, Shenzhen 518055, Peoples R China |
| Keywords | RESISTANCE GENES BACTERIAL COMMUNITIES EFFLUX PUMP PREVALENCE SALINITY IMPACT METAL ARGS |
| Issue Date | 10-Oct-2021 |
| Publisher | SCIENCE OF THE TOTAL ENVIRONMENT |
| Abstract | Although antimicrobial resistance genes (ARGs) in dozens of environments have been well documented, the distribution of ARGs in salt lake ecosystems has been less intensively investigated. In this study, the broad-spectrum ARG profiles, microbial community composition and the comprehensive associations between microbiome and antimicrobial resistome in four salt lakes were investigated using a metagenomic approach. A total of 175 ARG subtypes affiliated with 19 ARG types were detected, and ARGs conferring resistance to multidrug, bacitracin, and macrolide-lincosamide-streptogramin (MLS) accounted for 71.2% of the total ARG abundance. However, the abundance of ARGs significantly decreased with the increasing salinity in the lakes. Both ARG profiles and microbial community structure presented remarkable discrepancies in different lakes, as well as in different sample types. Microbes such as genera Azoarcus, Aeromonas, Pseudomonas, and Kocuria, significantly co-occurred with multiple ARGs, indicating that these bacteria are potential ARG hosts in salt lake ecosystems. Collectively, this work provides new insights into the occurrence and distribution of ARGs in salt lake ecosystems. (c) 2021 Elsevier B.V. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/623512 |
| ISSN | 0048-9697 |
| DOI | 10.1016/j.scitotenv.2021.148262 |
| Indexed | SCI(E) |
| Appears in Collections: | 深圳研究生院待认领 |
