| Title | Brain transcriptomics of nonhuman primates: A review |
| Authors | Pei, Wendi Fu, Lin Li, Shui-Qing Yu, Yang |
| Affiliation | Peking Univ Third Hosp, Beijing Key Lab Reprod Endocrinol & Assisted Repr, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing 100191, Peoples R China Peking Univ Third Hosp, Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China Peking Univ Third Hosp, Dept Pain, Beijing 100191, Peoples R China Peking Univ Third Hosp, Clin Stem Cell Res Ctr, Beijing 100191, Peoples R China |
| Issue Date | 14-May-2021 |
| Publisher | NEUROSCIENCE LETTERS |
| Abstract | The brain is one of the most important and intricate organs in our bodies. Interpreting brain function and illustrating the changes and molecular mechanisms during physiological or pathological processes are essential but sometimes difficult to achieve. In addition to histology, ethology and pharmacology, the development of transcriptomics alleviates this condition by enabling high-throughput observation of the brain at various levels of anatomical specificity. Moreover, because human brain samples are scarce, the brains of nonhuman primates are important alternative models. Here in this review, we summarize the applications of transcriptomics in nonhuman primate brain studies, including investigations of brain development, aging, toxic effects and diseases. Overall, as a powerful tool with developmental potential, transcriptomics has been widely utilized in neuroscience. |
| URI | http://hdl.handle.net/20.500.11897/622417 |
| ISSN | 0304-3940 |
| DOI | 10.1016/j.neulet.2021.135872 |
| Indexed | SCI(E) |
| Appears in Collections: | 第三医院 |
