| Title | CD38-Targeted Theranostics of Lymphoma with Zr-89/Lu-177-Labeled Daratumumab |
| Authors | Kang, Lei Li, Cuicui Rosenkrans, Zachary T. Huo, Nan Chen, Zhao Ehlerding, Emily B. Huo, Yan Ferreira, Carolina A. Barnhart, Todd E. Engle, Jonathan W. Wang, Rongfu Jiang, Dawei Xu, Xiaojie Cai, Weibo |
| Affiliation | Peking Univ First Hosp, Dept Nucl Med, Beijing 100034, Peoples R China Univ Wisconsin, Dept Radiol, Madison, WI 53705 USA Univ Wisconsin, Dept Pharmaceut Sci, Madison, WI 53705 USA Beijing Inst Biotechnol, Dept Med Mol Biol, Beijing 100850, Peoples R China Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Nucl Med, Wuhan 430022, Peoples R China |
| Keywords | IMMUNO-PET RADIONUCLIDE THERAPY MONOCLONAL-ANTIBODY TARGETED ALPHA RADIOIMMUNOTHERAPY CD38 RADIATION MODELS |
| Issue Date | May-2021 |
| Publisher | ADVANCED SCIENCE |
| Abstract | Lymphoma is a heterogeneous disease with varying clinical manifestations and outcomes. Many subtypes of lymphoma, such as Burkitt ' s lymphoma and diffuse large B cell lymphoma, are highly aggressive with dismal prognosis even after conventional chemotherapy and radiotherapy. As such, exploring specific biomarkers for lymphoma is of high clinical significance. Herein, a potential marker, CD38, is investigated for differentiating lymphoma. A CD38-targeting monoclonal antibody (mAb, daratumumab) is then radiolabeled with Zr-89 and Lu-177 for theranostic applications. As the diagnostic component, the Zr-89-labeled mAb is highly specific in delineating CD38-positive lymphoma via positron emission tomography (PET) imaging, while the Lu-177-labeled mAb serves well as the therapeutic component to suppress tumor growth after a one-time administration. These results strongly suggest that CD38 is a lymphoma-specific marker and prove that Zr-89/Lu-177-labeled daratumumab facilitates immunoPET imaging and radioimmunotherapy of lymphoma in preclinical models. Further clinical evaluation and translation of this CD38-targeted theranostics may be of significant help in lymphoma patient stratification and management. |
| URI | http://hdl.handle.net/20.500.11897/622288 |
| DOI | 10.1002/advs.202001879 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 |
