| Title | A deep learning model for diagnosing dystrophinopathies on thigh muscle MRI images |
| Authors | Yang, Mei Zheng, Yiming Xie, Zhiying Wang, Zhaoxia Xiao, Jiangxi Zhang, Jue Yuan, Yun |
| Affiliation | Peking Univ First Hosp, Dept Neurol, Beijing, Peoples R China Peking Univ, Acad Adv Interdisciplinary Studies, Beijing, Peoples R China Peking Univ First Hosp, Dept Radiol, Beijing, Peoples R China |
| Issue Date | 11-Jan-2021 |
| Publisher | BMC NEUROLOGY |
| Abstract | BackgroundDystrophinopathies are the most common type of inherited muscular diseases. Muscle biopsy and genetic tests are effective to diagnose the disease but cost much more than primary hospitals can reach. The more available muscle MRI is promising but its diagnostic results highly depends on doctors' experiences. This study intends to explore a way of deploying a deep learning model for muscle MRI images to diagnose dystrophinopathies.MethodsThis study collected 2536 T1WI images from 432 cases who had been diagnosed by genetic analysis and/or muscle biopsy, including 148 cases with dystrophinopathies and 284 cases with other diseases. The data was randomly divided into three sets: the data from 233 cases were used to train the CNN model, the data from 97 cases for the validation experiments, and the data from 102 cases for the test experiments. We also validated our models expertise at diagnosing by comparing the model's results on the 102 cases with those of three skilled radiologists.ResultsThe proposed model achieved 91% (95% CI: 0.88, 0.93) accuracy on the test set, higher than the best accuracy of 84% in radiologists. It also performed better than the skilled radiologists in sensitivity : sensitivities of the models and the doctors were 0.89 (95% CI: 0.85 0.93) versus 0.79 (95% CI:0.73, 0.84; p=0.190).ConclusionsThe deep model achieved excellent accuracy and sensitivity in identifying cases with dystrophinopathies. The comparable performance of the model and skilled radiologists demonstrates the potential application of the model in diagnosing dystrophinopathies through MRI images. |
| URI | http://hdl.handle.net/20.500.11897/622050 |
| DOI | 10.1186/s12883-020-02036-0 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 前沿交叉学科研究院 |
