| Title | Associations of adverse pregnancy outcomes with high ambient air pollution exposure: Results from the Project ELEFANT |
| Authors | Chen, Juan Fang, Junkai Zhang, Ying Xu, Zhouyang Byun, Hyang-Min Li, Peng-hui Deng, Furong Guo, Xinbiao Guo, Liqiong Wu, Shaowei |
| Affiliation | Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing, Peoples R China Tianjin Inst Med & Pharmaceut Sci, Tianjin, Peoples R China Tianjin Med Univ Gen Hosp, Dept Obstet & Gynecol, Med Genet Lab, Tianjin, Peoples R China Newcastle Univ, Populat Hlth Sci Inst, Newcastle Upon Tyne, Tyne & Wear, England Tianjin Univ Technol, Sch Environm Sci & Safety Engn, Tianjin, Peoples R China Tianjin Univ, Inst Disaster Med, 92nd Weijin Rd, Tianjin 300072, Peoples R China Xi An Jiao Tong Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Hlth Sci Ctr, Xian, Peoples R China Peking Univ, Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing, Peoples R China |
| Keywords | FINE PARTICULATE MATTER LOW-BIRTH-WEIGHT PRETERM BIRTH MATERNAL EXPOSURE OZONE THERAPY TERM RISK PM2.5 POLLUTANTS AUSTRALIA |
| Issue Date | 20-Mar-2021 |
| Publisher | SCIENCE OF THE TOTAL ENVIRONMENT |
| Abstract | Background: Investigations on the potential effects of high air pollution exposure before pregnancy on adverse pregnancy outcomes are limited, and it is unknown whether air quality standards looser than that set by World Health Organization (WHO) still can provide sufficient protection pregnant women from adverse pregnancy outcomes. Objectives: To evaluate the potential effects of high ambient air pollution around pregnancy on preterm birth (PTB) and low birth weight (LBW), and assess the risk of PTB and LBW associated with air pollutants with reference to different air quality standards of WHO and China. Methods: Our study leveraged 10,960 pregnant women from the Project ELEFANT. Daily average particulate matter with an aerodynamic diameter of <= 2.5 mu m (PM2.5) and <= 10 mu m (PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon monoxide (CO) and ozone (O-3) concentrations were collected based on Chinese Air Quality Reanalysis datasets. Hazard ratios (HR) of PTB and LBW were estimated for maternal PM2.5, PM10, NO2, SO2, CO and O-3 exposures and related proportions of days with daily average air pollution concentrations exceeding air quality standards of WHO and China around pregnancy using Cox proportional hazards regression models with adjustment for potential confounders. Results: Ambient PM2.5, PM10, NO2, SO2 and CO exposure during the before pregnancy and pregnancy period were both significantly and positively associated with increased risk of PTB, PTB subtypes and LBW. A 10% increase in proportion of days with daily average PM2.5 exceeding 25 mu g/m(3) over the entire pregnancy was most apparently associated with risk of PTB (HR, 12.66; 95% CI, 8.2019.53) and LBW (HR, 17.42; 95% CI, 6.8844.10) among all PM2.5 proportion variables based on different air quality standards. Conclusion: Air quality standards of WHO are necessary to be implemented to control for risks of adverse pregnancy outcomes associated with ambient air pollution in areas with high air pollution levels. (C) 2020 Elsevier B.V. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/621946 |
| ISSN | 0048-9697 |
| DOI | 10.1016/j.scitotenv.2020.143218 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 分子心血管学教育部重点实验室 |
