| Title | Obstetric and neonatal outcomes after the transfer of vitrified-warmed blastocysts developing from nonpronuclear and monopronuclear zygotes: a retrospective cohort study |
| Authors | Li, Ming Huang, Jin Zhuang, Xinjie Lin, Shengli Dang, Yujiao Wang, Ying Liu, Dandan Li, Rong Liu, Ping Qiao, Jie |
| Affiliation | Peking Univ Third Hosp, Dept Obstet & Gynecol, Ctr Reprod Med Ctr, Beijing, Peoples R China Peking Univ, Key Lab Assisted Reprod, Minist Educ, Beijing, Peoples R China Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China Natl Clin Res Ctr Obstet & Gynecol, Beijing, Peoples R China |
| Keywords | IN-VITRO FERTILIZATION INTRACYTOPLASMIC SPERM INJECTION PRONUCLEAR OOCYTE BIRTH-WEIGHT EMBRYOS SINGLE TIME IVF IDENTIFICATION CONSTITUTION |
| Issue Date | Jan-2021 |
| Publisher | FERTILITY AND STERILITY |
| Abstract | Objective: To evaluate the obstetric and neonatal outcomes after the transfer of vitrified-warmed single blastocysts developing from nonpronuclear (OPN) and monopronuclear (IPN) zygotes. Design: Cohort study. Setting: Affiliated hospital. Patient(s): This study was a retrospective analysis of 435 OPN and 281 1PN vitrified-warmed single blastocyst transfers, and 151 OPN and 75 1PN singletons, compared with 13,167 two-pronuclear (2PN) vitrified-warmed single blastocyst transfers and 4,559 2PN singletons, respectively. Intervention(s): None. Main Outcome Measure(s): Pregnancy rate (PR), abortion rate (AR), live birth rate (LBR), and singleton birthweight were the primary outcome measures. Result(s): PR, AR, and LBR were similar when compared between the OPN and 2PN groups after vitrified-warmed blastocyst transfer. However, the OPN group had a higher birthweights, higher z scores, and a greater proportion of very large for gestational age newborns. When comparing the 1PN and 2PN groups, we found that the PR was similar whereas the AR was higher and the LBR was lower. No differences were detected in the other neonatal outcomes. Conclusion(s): The results of the present study show that the transfer of 2PN blastocysts should be prioritized because of a higher AR and a lower LBR after IPN blastocyst transfers and a higher birthweight after OPN blastocyst transfers when compared with 2PN blastocyst transfers. Our data indicate the need for concern about the safety of 1PN and OPN embryo transfers. (C) 2020 by American Society for Reproductive Medicine. |
| URI | http://hdl.handle.net/20.500.11897/621944 |
| ISSN | 0015-0282 |
| DOI | 10.1016/j.fertnstert.2020.07.019 |
| Indexed | SCI(E) |
| Appears in Collections: | 第三医院 |
