| Title | An update on the roles of circular RNAs in osteosarcoma |
| Authors | Li, Zheng Li, Xingye Xu, Derong Chen, Xin Li, Shugang Zhang, Lin Chan, Matthew T. V. Wu, William K. K. |
| Affiliation | Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthopaed Surg, Beijing, Peoples R China Tsinghua Univ, Peking Univ, Dept Orthoped Surg,Beijing Jishuitan Hosp, Clin Coll 4,Jishuitan Orthopaed Coll, Beijing, Peoples R China Qingdao Univ, Affiliated Hosp, Dept Orthoped, Qingdao, Peoples R China Chinese Univ Hong Kong, Peter Hung Pain Res Inst, Dept Anaesthesia & Intens Care, Hong Kong, Peoples R China Chinese Univ Hong Kong, Inst Digest Dis, Ctr Gut Microbiota Res, State Key Lab Digest Dis, Hong Kong, Peoples R China Chinese Univ Hong Kong, LKS Inst Hlth Sci, Hong Kong, Peoples R China |
| Keywords | CELL-PROLIFERATION ENDOGENOUS RNA PROGRESSION PROMOTES METASTASIS PATHWAY GROWTH ACTS AMPLIFICATION EXPRESSION |
| Issue Date | Jan-2021 |
| Publisher | CELL PROLIFERATION |
| Abstract | Osteosarcoma is the most common primary bone malignancy and is a neoplasm thought to be derived from the bone-forming mesenchymal stem cells. Aberrant activation of oncogenes and inactivation of tumour suppressor genes by somatic mutations and epigenetic mechanisms play a pivotal pathogenic role in osteosarcoma. Aside from alterations in these protein-coding genes, it has now been realized that dysregulation of non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and the recently discovered circular RNAs (circRNAs), is crucial to the initiation and progression of osteosarcoma. CircRNAs are single-stranded RNAs that form covalently closed loops and function as an important regulatory element of the genome through multiple machineries. Recently, an increasing number of studies suggested that circRNAs also played critical roles in osteosarcoma. This review summarizes recent development and progression in circRNA transcriptome analysis and their functions in the modulation of osteosarcoma progression. |
| URI | http://hdl.handle.net/20.500.11897/621698 |
| ISSN | 0960-7722 |
| DOI | 10.1111/cpr.12936 |
| Indexed | SCI(E) |
| Appears in Collections: | 北京积水潭医院 |
