| Title | Differences in transcriptome response to air pollution exposure between adult residents with and without chronic obstructive pulmonary disease in Beijing: A panel study |
| Authors | Yao, Yuan Chen, Xi Chen, Wu Han, Yiqun Xue, Tao Wang, Junxia Qiu, Xinghua Que, Chengli Zheng, Mei Zhu, Tong |
| Affiliation | Peking Univ, Coll Environm Sci & Engn, SKL ESPC, Beijing 100871, Peoples R China Peking Univ, Coll Environm Sci & Engn, BIC ESAT, Beijing 100871, Peoples R China Peking Univ, Dept Resp Dis, Peking Univ First Hosp, Beijing 100034, Peoples R China Shenzhen Inst Bldg Res Co Ltd, GRiC, Shenzhen 518049, Peoples R China Imperial Coll London, MRC Ctr Environm & Hlth, Dept Epidemiol & Biostat, London W12 0BZ, England Peking Univ, Inst Reprod & Child Health, Minist Hlth, Key Lab Reprod Hlth, Beijing 100191, Peoples R China Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China |
| Keywords | ENDOTHELIAL GROWTH-FACTOR GENE-EXPRESSION SIGNALING PATHWAY OXIDATIVE STRESS PM2.5 EXPOSURE LUNG HEALTH ASSOCIATION SIGNATURE DIAGNOSIS |
| Issue Date | 15-Aug-2021 |
| Publisher | JOURNAL OF HAZARDOUS MATERIALS |
| Abstract | Ambient air pollution is a major risk factor for the prevalence and exacerbation of chronic obstructive pulmonary disease (COPD). Based on the COPDB (COPD in Beijing) panel study, whole-blood transcriptomes were repeatedly measured in 48 COPD patients and 62 healthy participants. Ambient mass concentrations of fine particulate matter (PM2.5), temperature, and relative humidity were continuously monitored at a monitoring station. The linear mixed-effects models were applied to estimate the associations between logarithmically transformed transcript levels and 1-day (d), 7-d, and 14-d average concentrations of PM2.5 before the start of follow-up visits. MetaCore (TM) was used to conduct the pathway enrichment analyses. Exposure to 1-, 7-, and 14-d average concentrations of PM2.5 was significantly associated with the transcriptome responses in both groups. The top 10, top 100, and top 1000 PM2.5-associated transcripts differed greatly between the two groups. Among COPD patients, role of alpha-6/beta-4 integrins in carcinoma progression, Notch signaling in breast cancer, and ubiquinone metabolism were the most significantly enriched PM2.5-associated biological pathways in the three time windows, respectively. In healthy participants, pro-opiomelanocortin processing was the most significant PM2.5-associated biological pathway in all three time windows. Our findings provide novel insights into the adverse health effects of air pollution exposure. |
| URI | http://hdl.handle.net/20.500.11897/618199 |
| ISSN | 0304-3894 |
| DOI | 10.1016/j.jhazmat.2021.125790 |
| Indexed | EI SCI(E) |
| Appears in Collections: | 环境科学与工程学院 第一医院 公共卫生学院 |
