| Title | Attenuated and delayed niacin skin flushing in schizophrenia and affective disorders: A potential clinical auxiliary diagnostic marker |
| Authors | Wang, Dan-Dan Hu, Xiao-Wen Jiang, Jie Sun, Li-Ya Qing, Ying Yang, Xu-Han Gao, Yan Cui, Gao-Ping Li, Ming-Hui Wang, Peng-Kun Zhang, Juan Zhuang, Yan Li, Ze-Zhi Li, Jing Guan, Li-Li Zhang, Tian-Hong Wang, Ji-Jun Ji, Feng Wan, Chun-Ling |
| Affiliation | Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Biox Inst, Shanghai, Peoples R China Shanghai Jiao Tong Univ, Minist Educ, Shanghai Key Lab Psychiat Disorders, Key Lab Genet Dev & Neuropsychiat Disorders, Shanghai, Peoples R China Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Dept Obstet & Gyneocol, Shanghai, Peoples R China Shanghai Jiao Tong Univ, Ren Ji Hosp, Sch Med, Dept Neurol, Shanghai, Peoples R China Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Dept Bioinformat & Biostat, Shanghai, Peoples R China Peking Univ, Hosp 6, Beijing, Peoples R China Inst Mental Hlth, Beijing, Peoples R China Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China Jining Med Univ, Inst Mental Hlth, 133 Hehua Rd, Jining 272000, Shandong, Peoples R China |
| Keywords | POLYUNSATURATED FATTY-ACIDS INDUCED VASODILATION ARACHIDONIC-ACID ABSENT RESPONSE METHYLNICOTINATE HALOPERIDOL HYPOTHESIS DECREASES RELEVANCE TURNOVER |
| Issue Date | Apr-2021 |
| Publisher | SCHIZOPHRENIA RESEARCH |
| Abstract | Aim: Schizophrenia and affective disorders all show high heterogeneity in clinical manifestations. A lack of objective biomarkers has long been a challenge in the clinical diagnosis of these diseases. In this study, we aimed to investigate the performance of niacin skin flushing in schizophrenia and affective disorders and determine its clinical potential as an auxiliary diagnostic marker. Methods: In this case-control study, niacin skin-flushing tests were conducted in 613 patients (including 307 schizophrenia patients, 179 bipolar disorder patients, and 127 unipolar depression patients) and 148 healthy controls (HCs) with a modified method. Differences in niacin skin-flushing responses were compared with adjustment for gender, BMI, age, nicotine dependence, alcohol consumption and educational status. A diagnostic model was established based on a bivariate cut-off. Results: Schizophrenia and affective disorders showed similar performance of niacin bluntness, characterized by attenuated flushing extent and reduced flushing rate. An innovative bivariate cut-off was established according to these two features, by which we could identify-patients with either schizophrenia or affective disorders from HCs with a sensitivity of 55.28%, a specificity of 83.56% and a positive predictive value of 93.66%. Conclusions: The niacin-induced skin flushing was prevalently blunted in patients with schizophrenia or affective disorders, indicating a promising potential as an auxiliary diagnostic marker in risk prediction and clinical management of these disorders. Additionally, the niacin-blunted subgroup implies a common biological basis in the investigated disorders, which provokes new thoughts in elucidating the pathological mechanisms. (c) 2021 Elsevier B.V. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/618112 |
| ISSN | 0920-9964 |
| DOI | 10.1016/j.schres.2021.02.009 |
| Indexed | SCI(E) SSCI |
| Appears in Collections: | 第六医院 |
