| Title | Mental Health in Persons With Chronic Myeloid Leukemia During the SARS-CoV-2 Pandemic: The Need for Increased Access to Health Care Services |
| Authors | Bao, Mei Yang, Sen Gale, Robert Peter Zhang, Yanli Liu, Xiaoli Zhu, Huanling Liang, Rong Liu, Bingcheng Zhou, Li Li, Zongru Dou, Xuelin Shi, Dayu Wang, Tao Meng, Li Li, Weiming Jiang, Qian |
| Affiliation | Peking Univ Peoples Hosp, Peking Univ Inst Hematol, Natl Clin Res Ctr Hematol Dis, Beijing, Peoples R China Imperial Coll London, Hematol Res Ctr, Dept Med, Div Expt Med, London, England Zhengzhou Univ, Henan Prov Tumor Hosp, Dept Hematol, Affiliated Canc Hosp, Zhengzhou, Peoples R China Southern Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou, Peoples R China Sichuan Univ, West China Hosp, Dept Hematol, Chengdu, Peoples R China Air Force Med Univ, Xijing Hosp, Dept Hematol, Xian, Peoples R China Chinese Acad Med Sci, Natl Clin Res Ctr Blood Dis, Inst Hematol, State Key Lab Expt Hematol, Tianjin, Peoples R China Shanghai Jiao Tong Univ, Natl Res Ctr Translat Med Shanghai, Shanghai Inst Hematol, State Key Lab Med Genom,Ruijin Hosp,Sch Med, Shanghai, Peoples R China Peking Univ, Hlth Sci Ctr, Dept Epidemiol & Biostat, Sch Publ Hlth, Beijing, Peoples R China Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Hematol, Wuhan, Peoples R China Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Hematol, Wuhan, Peoples R China |
| Keywords | GENERALIZED ANXIETY DISORDER QUALITY-OF-LIFE COVID-19 CANCER POPULATION DEPRESSION PREVALENCE |
| Issue Date | 8-Jun-2021 |
| Publisher | FRONTIERS IN PSYCHIATRY |
| Abstract | Mental health problems in the general population have been reported during the SARS-CoV-2 pandemic; however, there were rare data in persons with chronic myeloid leukemia (CML). Therefore, we performed a cross-sectional study on mental health evaluated using the 9-item Patient Health Questionnaire (PHQ-9; depression), the 7-item Generalized Anxiety Disorder (GAD-7; anxiety), and the 22-item Impact of Event Scale-Revised (IES-R; distress), including subscales of avoidance, intrusion, and hyper-arousal in persons with CML, non-cancer persons, and immediate family members of persons with cancer as controls (>= 16 years) by an online survey. Data from 3,197 persons with CML and 7,256 controls were collected. In multivariate analyses, CML was significantly associated with moderate to severe depression (OR = 1.6; 95% Confidence Interval [CI], 1.4, 1.9; p < 0.001), anxiety (OR = 1.4 [1.1, 1.7]; p = 0.001), distress (OR = 1.3 [1.1, 1.5]; p < 0.001), and hyper-arousal (OR = 1.5 [1.3, 1.6]; p < 0.001). Moreover, delay in regular monitoring was significantly associated with depression (OR 1.3 [1.0, 1.7]; p = 0.024), anxiety (OR = 1.3 [1.0, 1.8]; p = 0.044), avoidance (OR = 1.2 [1.0, 1.4]; p = 0.017), and intrusion (OR = 1.2 [1.0, 1.4]; p = 0.057); tyrosine kinase-inhibitor dose reduction or discontinuation, depression (OR = 1.9 [1.3, 2.8]; p = 0.001), distress (OR = 2.0 [1.4, 2.8]; p < 0.001), avoidance (OR = 1.6 [1.2, 2.1]; p = 0.004), intrusion (OR = 1.6 [1.1, 2.1]; p = 0.006), and hyper-arousal (OR = 1.3 [1.0, 1.8]; p = 0.088). We concluded that persons with CML during the SARS-CoV-2 pandemic have worse mental health including depression, anxiety, and distress symptoms. Decreasing or stopping monitoring or dose resulted in adverse mental health consequences. |
| URI | http://hdl.handle.net/20.500.11897/618099 |
| ISSN | 1664-0640 |
| DOI | 10.3389/fpsyt.2021.679932 |
| Indexed | SCI(E) SSCI |
| Appears in Collections: | 人民医院 |
