| Title | Novel, emerging and provisional renal entities: The Genitourinary Pathology Society (GUPS) update on renal neoplasia |
| Authors | Trpkov, Kiril Williamson, Sean R. Gill, Anthony J. Adeniran, Adebowale J. Agaimy, Abbas Alaghehbandan, Reza Amin, Mahul B. Argani, Pedram Chen, Ying-Bei Cheng, Liang Epstein, Jonathan, I Cheville, John C. Comperat, Eva da Cunha, Isabela Werneck Gordetsky, Jennifer B. Gupta, Sounak He, Huiying Hirsch, Michelle S. Humphrey, Peter A. Kapur, Payal Kojima, Fumiyoshi Lopez, Jose, I Maclean, Fiona Magi-Galluzzi, Cristina McKenney, Jesse K. Mehra, Rohit Menon, Santosh Netto, George J. Przybycin, Christopher G. Rao, Priya Rao, Qiu Reuter, Victor E. Saleeb, Rola M. Shah, Rajal B. Smith, Steven C. Tickoo, Satish Tretiakova, Maria S. True, Lawrence Verkarre, Virginie Wobker, Sara E. Zhou, Ming Hes, Ondrej |
| Affiliation | Univ Calgary, Cumming Sch Med, Dept Pathol & Lab Med, Calgary, AB, Canada Cleveland Clin, Robert J Tomsich Pathol & Lab Med Inst, Cleveland, OH USA Univ Sydney, Sydney Med Sch, Sydney, NSW, Australia Kolling Inst Med Res, Canc Diag & Pathol Grp, Sydney, NSW, Australia Royal North Shore Hosp, Dept Anat Pathol, NSW Hlth Pathol, Sydney, NSW, Australia Yale Sch Med, Dept Pathol, New Haven, CT USA Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Inst Pathol, Erlangen, Germany Univ British Columbia, Royal Columbian Hosp, Fac Med, Dept Pathol, Vancouver, BC, Canada Univ Tennessee Hlth Sci, Dept Pathol & Lab Med & Urol, Memphis, TN USA Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA Johns Hopkins Med Inst, Dept Oncol, Baltimore, MD 21205 USA Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA Indiana Univ, Dept Pathol & Lab Med, Sch Med, Indianapolis, IN USA Johns Hopkins Med Inst, Dept Urol, Baltimore, MD USA Mayo Clin, Dept Pathol, Rochester, MN USA Sorbonne Univ, Dept Pathol, Hop Tenon, Paris, France Rede DOR Sao Luiz, Pathol Dept, Sao Paulo, SP, Brazil Vanderbilt Univ, Dept Pathol Microbiol & Immunol, Med Ctr, Nashville, TN USA Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing, Peoples R China Brigham & Womens Hosp, Dept Pathol, Harvard Med Sch, Boston, MA USA Univ Texas Southwestern Med Ctr, Dept Pathol, Kidney Canc Program, Simmons Comprehens Canc Ctr, Dallas, TX USA Univ Texas Southwestern Med Ctr, Dept Urol, Kidney Canc Program, Simmons Comprehens Canc Ctr, Dallas, TX USA Wakayama Med Univ, Dept Human Pathol, Wakayama, Japan Cruces Univ Hosp, Biocruces Bizkaia Inst, Dept Pathol, Bizkaia, Spain Macquarie Univ, Fac Med Hlth & Human Sci, Dept Clin Med, Sydney, NSW, Australia Douglass Hanly Moir Pathol, Anat Pathol, Sydney, NSW, Australia Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI USA Univ Michigan, Michigan Ctr Translat Pathol, Med Sch, Ann Arbor, MI USA Tata Mem Hosp, Dept Surg Pathol, Parel, India Homi Bhabha Natl Inst, Mumbai, Maharashtra, India Univ Texas Houston, MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA Nanjing Univ, Jinling Hosp, Dept Pathol, Sch Med, Nanjing, Peoples R China Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada Univ Texas Southwestern Med Ctr, Dept Pathol, Dallas, TX USA VCU Sch Med, Dept Pathol, Richmond, VA USA VCU Sch Med, Dept Urol, Richmond, VA USA Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA Hop Europeen Georges Pompidou, Assistance Publ Hop Paris, Dept Pathol, Paris, France Univ Paris, Equipe Labellisee Ligue Canc, INSERM, PARCC, F-75015 Paris, France Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC USA Univ N Carolina, Dept Urol, Chapel Hill, NC USA Tufts Med Ctr, Dept Pathol, Boston, MA USA Charles Univ Prague, Fac Med, Dept Pathol, Plzen, Czech Republic Univ Hosp Plzen, Plzen, Czech Republic |
| Issue Date | Feb-2021 |
| Publisher | MODERN PATHOLOGY |
| Abstract | The Genitourinary Pathology Society (GUPS) undertook a critical review of the recent advances in renal neoplasia, particularly focusing on the newly accumulated evidence post-2016 World Health Organization (WHO) classification. In the era of evolving histo-molecular classification of renal neoplasia, morphology is still key. However, entities (or groups of entities) are increasingly characterized by specific molecular features, often associated either with recognizable, specific morphologies or constellations of morphologies and corresponding immunohistochemical profiles. The correct diagnosis has clinical implications leading to better prognosis, potential clinical management with targeted therapies, may identify hereditary or syndromic associations, which may necessitate appropriate genetic testing. We hope that this undertaking will further facilitate the identification of these entities in practice. We also hope that this update will bring more clarity regarding the evolving classification of renal neoplasia and will further reduce the category of "unclassifiable renal carcinomas/tumors". We propose three categories of novel entities: (1) "Novel entity", validated by multiple independent studies; (2) "Emerging entity", good compelling data available from at least two or more independent studies, but additional validation is needed; and (3) "Provisional entity", limited data available from one or two studies, with more work required to validate them. For some entities initially described using different names, we propose new terminologies, to facilitate their recognition and to avoid further diagnostic dilemmas. Following these criteria, we propose as novel entities: eosinophilic solid and cystic renal cell carcinoma (ESC RCC), renal cell carcinoma with fibromyomatous stroma (RCC FMS) (formerly RCC with leiomyomatous or smooth muscle stroma), and anaplastic lymphoma kinase rearrangement-associated renal cell carcinoma (ALK-RCC). Emerging entities include: eosinophilic vacuolated tumor (EVT) and thyroid-like follicular renal cell carcinoma (TLFRCC). Finally, as provisional entities, we propose low-grade oncocytic tumor (LOT), atrophic kidney-like lesion (AKLL), and biphasic hyalinizing psammomatous renal cell carcinoma (BHP RCC). |
| URI | http://hdl.handle.net/20.500.11897/617508 |
| ISSN | 0893-3952 |
| DOI | 10.1038/s41379-021-00737-6 |
| Indexed | SCI(E) |
| Appears in Collections: | 医学部待认领 |
