| Title | Application Value of Shear Wave Elastography in the Evaluation of Tumor Downstaging for Locally Advanced Rectal Cancer After Neoadjuvant Chemoradiotherapy |
| Authors | Cong, Yue Fan, Zhihui Dai, Ying Zhang, Zhongyi Yan, Kun |
| Affiliation | Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing,Dept Ultrasound, 52 Fucheng Rd, Beijing 100142, Peoples R China |
| Keywords | PREOPERATIVE CHEMORADIOTHERAPY ULTRASOUND |
| Issue Date | Jan-2021 |
| Publisher | JOURNAL OF ULTRASOUND IN MEDICINE |
| Abstract | Objectives The aim of this study was to assess the application value of shear wave elastography in the evaluation of tumor downstaging for locally advanced rectal cancer after neoadjuvant chemoradiotherapy. Methods A retrospective analysis was conducted using data from patients with locally advanced rectal cancer treated in our hospital who received endorectal ultrasound (ERUS) and shear wave elastographic examinations before and after chemoradiotherapy. The cases were grouped according to the postoperative pathologic tumor-staging scores. The lesions were divided into 2 groups: 1 showing and the other not showing tumor downstaging. The efficacy of ERUS in diagnosis of tumor downstaging was calculated. The differences in the mean and maximum values of the Young modulus of the lesions before and after chemoradiotherapy between the groups were calculated and compared. Receiver operating characteristic curves were constructed by using the differences in the 2 kinds of values of the Young modulus. Results The mean and maximum values of the Young modulus before and after chemoradiotherapy were significantly different (P < .05). The differences in the mean and maximum values of the Young modulus of rectal lesions between groups were statistically significant (P < .05). The results of the receiver operating characteristic curve showed that a difference in the mean value at 34.7 kPa was the optimal diagnostic threshold. Compared with ERUS, this standard showed a significant difference in diagnosis of tumor downstaging (P < .05). Conclusions Shear wave elastography is an effective ultrasound elastographic technique to assist ERUS in evaluating lesions after chemoradiotherapy in rectal cancer. It can improve the diagnostic efficacy of tumor downstaging and provide effective imaging conclusions for clinical decision making. |
| URI | http://hdl.handle.net/20.500.11897/617197 |
| ISSN | 0278-4297 |
| DOI | 10.1002/jum.15378 |
| Indexed | EI SCI(E) |
| Appears in Collections: | 北京肿瘤医院 |
