| Title | Viral dynamics and antibody responses in people with asymptomatic SARS-CoV-2 infection |
| Authors | Sui, Zhiwei Dai, Xinhua Lu, Qingbin Zhang, Yulan Huang, Min Li, Shufen Peng, Tao Xie, Jie Zhang, Yongzhuo Wu, Chunchen Xia, Jianbo Dong, Lianhua Yang, Jiayi Huang, Wenfeng Liu, Siyuan Wang, Ziquan Li, Ke Yang, Qingfang Zhou, Xi Wu, Ying Liu, Wei Fang, Xiang Peng, Ke |
| Affiliation | Natl Inst Metrol, Ctr Adv Measurement Sci, Beijing, Peoples R China Peking Univ, Sch Publ Hlth, Dept Laboratorial Sci & Technol, Beijing, Peoples R China Chinese Acad Sci, Ctr Biosafety Mega Sci, State Key Lab Virol, Wuhan, Hubei, Peoples R China Wuhan Inst Virol, Joint Lab Infect Dis & Hlth, Wuhan, Peoples R China Wuhan Jinyintan Hosp, Wuhan, Peoples R China Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Lab Med,HUST, Wuhan, Hubei, Peoples R China Huazhong Univ Sci & Technol, Tongji Med Coll, Maternal & Child Hlth Hosp Hubei Prov, Dept Lab, Wuhan, Peoples R China Shenzhen Mindray Biomed Elect Co Ltd, Shenzhen, Peoples R China Univ Chinese Acad Sci, Beijing, Peoples R China Wuhan Univ, Inst Med Virol, Sch Basic Med Sci, State Key Lab Virol, Wuhan, Peoples R China Beijing Inst Microbiol & Epidemiol, Key Lab Pathogen & Biosecur, Beijing, Peoples R China |
| Keywords | HERD-IMMUNITY |
| Issue Date | 10-May-2021 |
| Publisher | SIGNAL TRANSDUCTION AND TARGETED THERAPY |
| Abstract | Over 40% of the coronavirus disease 2019 (COVID-19) COVID-19 patients were asymptomatically infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the immune responses of these asymptomatic individuals is a critical factor for developing the strategy to contain the COVID-19 pandemic. Here, we determined the viral dynamics and antibody responses among 143 asymptomatic individuals identified in a massive screening of more than 5 million people in eight districts of Wuhan in May 2020. Asymptomatic individuals were admitted to the government-designated centralized sites in accordance with policy. The incidence rate of asymptomatic infection is similar to 2.92/100,000. These individuals had low viral copy numbers (peaked at 315 copies/mL) and short-lived antibody responses with the estimated diminish time of 69 days. The antibody responses in individuals with persistent SARS-CoV-2 infection is much longer with the estimated diminish time of 257 days. These results imply that the immune responses in the asymptomatic individuals are not potent enough for preventing SARS-CoV-2 re-infection, which has recently been reported in recovered COVID-19 patients. This casts doubt on the efficacy of forming "herd-immunity" through natural SARS-CoV-2 infection and urges for the development of safe and effective vaccines. |
| URI | http://hdl.handle.net/20.500.11897/614561 |
| ISSN | 2095-9907 |
| DOI | 10.1038/s41392-021-00596-2 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 |
