| Title | Health-related quality of life in Chinese population with non-alcoholic fatty liver disease: a national multicenter survey |
| Authors | Huang, Rui Fan, Jian-Gao Shi, Jun-Ping Mao, Yi-Min Wang, Bing-Yuan Zhao, Jing-Min Lu, Lun-Gen Zhong, Bi-Hui Zou, Zheng-Sheng Xu, You-Qing Ye, Yi-Nong Liu, Long-Gen Lin, Lian-Jie Li, Jian-Ping Rao, Hui-Ying Wei, Lai |
| Affiliation | Peking Univ, Beijing Int Cooperat Base Sci & Technol NAFLD Dia, Beijing Key Lab Hepatitis C & Immunotherapy Liver, Peoples Hosp,Hepatol Inst, 11 Xizhimen South St, Beijing 100044, Peoples R China Shanghai Jiao Tong Univ, Sch Med, Dept Digest, Xinhua Hosp, Shanghai, Peoples R China Hangzhou Normal Univ, Affiliated Hosp, Dept Hepatol, Hangzhou, Peoples R China Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Digest, Shanghai, Peoples R China China Med Univ, Hosp 1, Dept Digest, Shenyang, Peoples R China Peoples Liberat Army Gen Hosp, Med Ctr 5, Dept Pathol, Beijing, Peoples R China Shanghai Jiao Tong Univ, Peoples Hosp 1, Sch Med, Dept Digest, Shanghai, Peoples R China Sun Yat Sen Univ, Affiliated Hosp 1, Dept Digest, Guangzhou, Peoples R China Capital Med Univ, Beijing Tiantan Hosp, Dept Digest, Beijing, Peoples R China First Hosp Fushan, Dept Infect Dis, Fushan, Peoples R China Third Peoples Hosp, Dept Hepatol, Changzhou, Jiangsu, Peoples R China China Med Univ, Shengjing Hosp, Dept Digest, Shenyang, Peoples R China China Resources Sanjiu Med & Pharmaceut Co Ltd, Shenzhen, Peoples R China Tsinghua Univ, Beijing Tsinghua Changgung Hosp, Hepatopancreatobiliary Ctr, 168 Litang Rd, Beijing 102218, Peoples R China |
| Keywords | WEIGHT-LOSS QUESTIONNAIRE IMPROVEMENTS IMPACT NAFLD CLDQ |
| Issue Date | 7-May-2021 |
| Publisher | HEALTH AND QUALITY OF LIFE OUTCOMES |
| Abstract | Background Health Related Quality of Life (HRQL) is a multi-dimensional construct that can comprehensively evaluate the patient's health status, including physical, emotional, mental and social well-being. In this study, we aimed to evaluate the impact of non-alcoholic fatty liver disease (NAFLD) on HRQL in a Chinese population. Methods In this national multicenter cross-sectional survey, patients with NAFLD were enrolled. Chronic Liver Disease Questionnaire (CLDQ)-NAFLD was used to qualify HRQL. Univariate and multivariate analysis were used to identify independent risk factors of HRQL. Results A total of 5181 patients with NAFLD from 90 centers were enrolled in this study (mean age, 43.8 +/- 13.3 years; male, 65.8%). The overall CLDQ score was 5.66 +/- 0.89. Multivariate logistic regression analysis showed that body mass index (BMI: HR, 1.642; 95% CI, 1.330-2.026), alanine transaminase (ALT: HR, 1.006; 95% CI, 1.001-1.011), triglyceride (HR, 1.184; 95% CI, 1.074-1.305), disease severity (HR, 3.203; 95% CI, 1.418-7.232) and cardiovascular disease (HR, 4.305; 95% CI, 2.074-8.939) were independent risk factors for overall CLDQ score. In the logistic analyses of individual domain, BMI and triglyceride were independent risk factors of all domains. ALT, disease severity, diabetes, depression and cardiovascular disease were influencing factors for the CLDQ score of several domains. Conclusions This national multicenter cross-sectional survey in China indicated that the HRQL in patients with NAFLD was impaired. HRQL was found to be significantly associated with sociodemographic and clinical factors. Attention should be paid to the optimally managing care of patients with NAFLD to improve their HRQL. |
| URI | http://hdl.handle.net/20.500.11897/613143 |
| DOI | 10.1186/s12955-021-01778-w |
| Indexed | SCI(E) SSCI |
| Appears in Collections: | 人民医院 |
