| Title | Does psychosocial stress modify the association of fine particulate matter and ozone with cardiovascular health indicators? |
| Authors | Chen, Qiao Li, Hongyu Liu, Qisijing Wang, Wanzhou Deng, Furong Sun, Zhiwei Guo, Xinbiao Wu, Shaowei |
| Affiliation | Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, 38 Xueyuan Rd, Beijing 100191, Peoples R China Capital Med Univ, Sch Publ Hlth, Dept Toxicol & Sanit Chem, Beijing 100069, Peoples R China Capital Med Univ, Beijing Key Lab Environm Toxicol, Beijing 100069, Peoples R China |
| Issue Date | 15-May-2021 |
| Publisher | ENVIRONMENTAL POLLUTION |
| Abstract | Fine particulate matter (PM2.5) and ozone (O-3) air pollution can cause abnormal changes in blood pressure (BP), blood glucose and lipids, which are important indicators for cardiovascular health. Psychosocial stress could be a potential effect modifier for adverse health effects of air pollution, but research evidence is scarce. A cross-sectional study with 373 elderly subjects was conducted in Beijing during 2018-2019. We collected psychosocial stress information on anxiety, perceived stress and depression, obtained daily environmental data, measured resting BP, blood glucose and lipids in study participants, and analyzed the associations of PM2.5 or O-3 with cardiovascular health indicators and the modification effect by psychosocial stress. Results showed that PM2.5 was significantly associated with increased systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure (PP); and O-3 was significantly associated with elevated DBP, glycated hemoglobin (HbA1c) and total triglyceride (TG). In addition, the associations of PM2.5 with TG, and O-3 with SBP and TG were higher in participants with high psychosocial stress, whereas the associations of O-3 with high-density lipoprotein cholesterol (HDLC) were higher in participants with low psychosocial stress. For an interquartile range (IQR) (56.8 mu g/m(3)) increase in PM2.5 at 4-d moving average, TG increased by 21.43% (95% CI: 2.90, 43.29) in high perceivedstress group, and decreased by 20.05% (95% CI: -30.31, -8.28) in low perceived-stress group (p for interaction = 0.04). For an IQR (63.0 mu g/m(3)) increase in O-3 at 2-d moving average, TG increased by 32.01% (95% CI: 7.65, 61.89) in high perceived-stress group, and increased by 7.95% (95% CI: -9.80, 29.20) only in low perceived-stress group (p for interaction = 0.04). For an IQR (64.0 mu g/m(3)) increase in O-3 at 3-d moving average, HDL-C decreased by 4.55% (95% CI: -12.15, 3.72) in high perceived-stress group, and increased by 0.57% (95% CI: -6.99, 8.75) in low perceived-stress group (p for interaction=0.002). In conclusion, our results indicated that short-term exposures to PM2.5 and O-3 were associated with significant changes in BP, blood glucose and lipids, and psychosocial stress may increase the susceptibility of the participants to the adverse cardiovascular effects of PM2.5 and O-3. (C) 2021 Elsevier Ltd. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/611569 |
| ISSN | 0269-7491 |
| DOI | 10.1016/j.envpol.2021.116726 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 |
