| Title | Associations between Osteocalcin, Calciotropic Hormones, and Energy Metabolism in a Cohort of Chinese Postmenopausal Women: Peking Vertebral Fracture Study |
| Authors | Jiajue, Ruizhi Liu, Shuying Pei, Yu Qi, Xuan Jiang, Yan Wang, Qiuping Wang, Wenbo Wang, Xiran Huang, Wei Zheng, Xin Ning, Zhiwei Wang, Ou Li, Mei Xing, Xiaoping Yu, Wei Xu, Ling Xia, Weibo |
| Affiliation | Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Endocrinol, Key Lab Endocrinol,Natl Commiss Hlth, 1 Shuaifuyuan,Wangfujing St, Beijing 100730, Peoples R China Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Endocrinol, Beijing 100853, Peoples R China Beijing Liangxiang Hosp, Dept Endocrinol, Beijing 102401, Peoples R China Peking Univ, Dept Endocrinol, Shougang Hosp, Beijing 102401, Peoples R China Gen Hosp Rocket Force, Dept Cadre Unit, Beijing 100088, Peoples R China Beijing Haidian Hosp, Dept Endocrinol, Beijing 100080, Peoples R China China Rehabil Res Ctr, Dept Endocrinol, Beijing 100068, Peoples R China Beijing Chaoyang Hosp, Dept Endocrinol, Beijing 100020, Peoples R China Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Radiol, Shuaifuyuan 1, Beijing 100730, Peoples R China Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Gynaecol & Obstet, Beijing 100730, Peoples R China |
| Issue Date | 25-Mar-2021 |
| Publisher | INTERNATIONAL JOURNAL OF ENDOCRINOLOGY |
| Abstract | Objective. The endocrine function of bone in energy metabolism may be mediated by the osteocalcin (OC). We examined the association between OC and energy metabolism among Chinese postmenopausal women. Design and Setting. A cross-sectional cohort study enrolling 1635 participants was conducted using data from the Peking Vertebral Fracture study. Partial correlation analysis was performed to explore the correlation of OC, parathyroid hormone (PTH), or 25-hydroxyvitamin D (25(OH)D) with glycemic and lipid metabolic parameters. A logistic regression model was used to investigate the association of OC, PTH, or 25(OH)D with the prevalence of diabetes and dyslipidemia. Results. Serum levels of OC, PTH, and 25(OH)D were all positively correlated with serum cholesterol levels, whereas only OC was negatively associated with serum glucose level. In the logistic regression model, both OC and PTH were negatively associated with the prevalence of diabetes (odds ratio [OR], 95% confidence interval [95% CI]: 0.967, 0.948-0.986 for OC and 0.986, 0.978-0.994 for PTH). No significant association was found between 25(OH)D and diabetes. Both OC and 25(OH)D, rather than PTH, were associated with abnormalities of high cholesterol levels, such as hypercholesterolemia and high LDL-C levels. Further classifying the population based on the median value of OC and PTH, low OC and low PTH subgroup had the highest OR, 95% CI for diabetes (1.873, 1.287-2.737) and the lowest OR, 95% CI for hypercholesterolemia (0.472, 0.324-0.688) and for high LDL-C (0.538, 0.376-0.771). Conclusion. Among Chinese postmenopausal women, a lower serum level of OC was associated with a higher prevalence of diabetes and lower serum cholesterol levels, and a low PTH concentration could magnify these associations. |
| URI | http://hdl.handle.net/20.500.11897/611540 |
| ISSN | 1687-8337 |
| DOI | 10.1155/2021/5585018 |
| Indexed | SCI(E) |
| Appears in Collections: | 首钢医院 |
