| Title | 3D Genome of macaque fetal brain reveals evolutionary innovations during primate corticogenesis |
| Authors | Luo, Xin Liu, Yuting Dang, Dachang Hu, Ting Hou, Yingping Meng, Xiaoyu Zhang, Fengyun Li, Tingting Wang, Can Li, Min Wu, Haixu Shen, Qiushuo Hu, Yan Zeng, Xuerui He, Xiechao Yan, Lanzhen Zhang, Shihua Li, Cheng Su, Bing |
| Affiliation | Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China Peking Univ, Ctr Bioinformat, Ctr Stat Sci, Sch Life Sci, Beijing 100871, Peoples R China Chinese Acad Sci, Acad Math & Syst Sci, RCSDS, NCMIS,CEMS, Beijing 100190, Peoples R China Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China Chinese Acad Sci, Kunming Inst Zool, Kunming Primate Res Ctr, Natl Resource Ctr Nonhuman Primates, Kunming 650107, Yunnan, Peoples R China Chinese Acad Sci, Kunming Inst Zool, Natl Res Facil Phenotyp & Genet Anal Model Anim P, Kunming 650107, Yunnan, Peoples R China Univ Chinese Acad Sci, Kunming Coll Life Sci, Beijing 100101, Peoples R China |
| Issue Date | 4-Feb-2021 |
| Publisher | CELL |
| Abstract | Elucidating the regulatory mechanisms of human brain evolution is essential to understanding human cognition and mental disorders. We generated multi-omics profiles and constructed a high-resolution map of 3D genome architecture of rhesus macaque during corticogenesis. By comparing the 3D genomes of human, macaque, and mouse brains, we identified many human-specific chromatin structure changes, including 499 topologically associating domains (TADs) and 1,266 chromatin loops. The human-specific loops are significantly enriched in enhancer-enhancer interactions, and the regulated genes show human-specific expression changes in the subplate, a transient zone of the developing brain critical for neural circuit formation and plasticity. Notably, many human-specific sequence changes are located in the human-specific TAD boundaries and loop anchors, which may generate new transcription factor binding sites and chromatin structures in human. Collectively, the presented data highlight the value of comparative 3D genome analyses in dissecting the regulatory mechanisms of brain development and evolution. |
| URI | http://hdl.handle.net/20.500.11897/610278 |
| ISSN | 0092-8674 |
| DOI | 10.1016/j.cell.2021.01.001 |
| Indexed | SCI(E) |
| Appears in Collections: | 生命科学学院 前沿交叉学科研究院 |
