| Title | Functions of Dendritic Cells and Its Association with Intestinal Diseases |
| Authors | Yang, Ze-Jun Wang, Bo-Ya Wang, Tian-Tian Wang, Fei-Fei Guo, Yue-Xin Hua, Rong-Xuan Shang, Hong-Wei Lu, Xin Xu, Jing-Dong |
| Affiliation | Capital Med Univ, Clin Med Program 5 3, Beijing 100069, Peoples R China Peking Univ, Undergrad Student Years Program Clin Med 2018 8, Hlth Sci Ctr, Beijing 100081, Peoples R China Capital Med Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100069, Peoples R China Capital Med Univ, Oral Med Program 5 3, Beijing 100069, Peoples R China Capital Med Univ, Sch Basic Med Sci, Morphol Expt Ctr, Beijing 100069, Peoples R China |
| Issue Date | Mar-2021 |
| Publisher | CELLS |
| Abstract | Dendritic cells (DCs), including conventional DCs (cDCs) and plasmacytoid DCs (pDCs), serve as the sentinel cells of the immune system and are responsible for presenting antigen information. Moreover, the role of DCs derived from monocytes (moDCs) in the development of inflammation has been emphasized. Several studies have shown that the function of DCs can be influenced by gut microbes including gut bacteria and viruses. Abnormal changes/reactions in intestinal DCs are potentially associated with diseases such as inflammatory bowel disease (IBD) and intestinal tumors, allowing DCs to be a new target for the treatment of these diseases. In this review, we summarized the physiological functions of DCs in the intestinal micro-environment, their regulatory relationship with intestinal microorganisms and their regulatory mechanism in intestinal diseases. |
| URI | http://hdl.handle.net/20.500.11897/610029 |
| DOI | 10.3390/cells10030583 |
| Indexed | SCI(E) |
| Appears in Collections: | 医学部待认领 |
