| Title | Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19 |
| Authors | Guo, Qirui Zhao, Yingchi Li, Junhong Liu, Jiangning Yang, Xiuhong Guo, Xuefei Kuang, Ming Xia, Huawei Zhang, Zeming Cao, Lili Luo, Yujie Bao, Linlin Wang, Xiao Wei, Xuemei Deng, Wei Wang, Nan Chen, Luoying Chen, Jingxuan Zhu, Hua Gao, Ran Qin, Chuan Wang, Xiangxi You, Fuping |
| Affiliation | Peking Univ, Beijing Key Lab Tumor Syst Biol, Sch Basic Med Sci, lInst Syst Biomed,Dept Immunol,Hlth Sci Ctr, Beijing, Peoples R China Chinese Acad Sci, Univ Chinese Acad Sci, CAS Key Lab Infect & Immun, Natl Lab Macromol,Inst Biophys, Beijing, Peoples R China Chinese Acad Med Sci, Key Lab Human Dis Comparat Med, Beijing Key Lab Anim Models Emerging & Remerging, Chinese Minist Hlth,Inst Lab Anim Sci, Beijing, Peoples R China Peking Union Med Coll, Comparat Med Ctr, Beijing, Peoples R China |
| Keywords | I INTERFERON CALPROTECTIN INFLAMMATION PNEUMONIA PROTEINS BINDING LETHAL |
| Issue Date | 10-Feb-2021 |
| Publisher | CELL HOST & MICROBE |
| Abstract | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic poses an unprecedented public health crisis. Evidence suggests that SARS-CoV-2 infection causes dysregulation of the immune system. However, the unique signature of early immune responses remains elusive. We characterized the transcriptome of rhesus macaques and mice infected with SARS-CoV-2. Alarmin S100A8 was robustly induced in SARS-CoV-2-infected animal models as well as in COVID-19 patients. Paquinimod, a specific inhibitor of S100A8/A9, could rescue the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice. Remarkably, Paquinimod treatment resulted in almost 100% survival in a lethal model of mouse coronavirus infection using the mouse hepatitis virus (MHV). A group of neutrophils that contributes to the uncontrolled pathological damage and onset of COVID-19 was dramatically induced by coronavirus infection. Paquinimod treatment could reduce these neutrophils and regain anti-viral responses, unveiling key roles of S100A8/A9 and aberrant neutrophils in the pathogenesis of COVID-19, highlighting new opportunities for therapeutic intervention. |
| URI | http://hdl.handle.net/20.500.11897/609912 |
| ISSN | 1931-3128 |
| DOI | 10.1016/j.chom.2020.12.016 |
| Indexed | SCI(E) |
| Appears in Collections: | 基础医学院 |
