| Title | Projections from D2 Neurons in Different Subregions of Nucleus Accumbens Shell to Ventral Pallidum Play Distinct Roles in Reward and Aversion |
| Authors | Yao, Yun Gao, Ge Liu, Kai Shi, Xin Cheng, Mingxiu Xiong, Yan Song, Sen |
| Affiliation | Tsinghua Univ, Dept Biomed Engn, Lab Brain & Intelligence, Beijing 100084, Peoples R China Tsinghua Univ, McGovern Inst Brain Res, Beijing 100084, Peoples R China Tsinghua Univ, Ctr Brain Inspired Comp Res, Beijing Innovat Ctr Future Chips, Beijing 100084, Peoples R China Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China Natl Inst Biol Sci, Beijing 102206, Peoples R China Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA Peking Univ, Sch Basic Med Sci, Neurosci Res Inst, Beijing 100191, Peoples R China Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing 100191, Peoples R China |
| Issue Date | Feb-2021 |
| Publisher | NEUROSCIENCE BULLETIN |
| Abstract | The nucleus accumbens shell (NAcSh) plays an important role in reward and aversion. Traditionally, NAc dopamine receptor 2-expressing (D2) neurons are assumed to function in aversion. However, this has been challenged by recent reports which attribute positive motivational roles to D2 neurons. Using optogenetics and multiple behavioral tasks, we found that activation of D2 neurons in the dorsomedial NAcSh drives preference and increases the motivation for rewards, whereas activation of ventral NAcSh D2 neurons induces aversion. Stimulation of D2 neurons in the ventromedial NAcSh increases movement speed and stimulation of D2 neurons in the ventrolateral NAcSh decreases movement speed. Combining retrograde tracing and in situ hybridization, we demonstrated that glutamatergic and GABAergic neurons in the ventral pallidum receive inputs differentially from the dorsomedial and ventral NAcSh. All together, these findings shed light on the controversy regarding the function of NAcSh D2 neurons, and provide new insights into understanding the heterogeneity of the NAcSh. |
| URI | http://hdl.handle.net/20.500.11897/608507 |
| ISSN | 1673-7067 |
| DOI | 10.1007/s12264-021-00632-9 |
| Indexed | SCI(E) |
| Appears in Collections: | 基础医学院 |
