| Title | Manganese nanodepot augments host immune response against coronavirus |
| Authors | Sun, Yizhe Yin, Yue Gong, Lidong Liang, Zichao Zhu, Chuanda Ren, Caixia Zheng, Nan Zhang, Qiang Liu, Haibin Liu, Wei You, Fuping Lu, Dan Lin, Zhiqiang |
| Affiliation | Peking Univ, Beijing Key Lab Tumor Syst Biol, Peking Tsinghua Ctr Life Sci, Inst Syst Biomed,Dept Pathol,Sch Basic Med Sci,Hl, Beijing 100191, Peoples R China Peking Univ, Hlth Sci Ctr, Dept Human Anat Histol & Embryol, Beijing 100191, Peoples R China Peking Univ, Key Lab Carcinogenesis & Translat Res, Natl Drug Clin Trial Ctr, Minist Educ,Canc Hosp & Inst, Beijing 100142, Peoples R China Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100191, Peoples R China Xinjiang Prod & Construct Corps Hosp, Dept Gen Surg, Urumqi 830002, Xinjiang Uygur, Peoples R China |
| Keywords | STRATEGIES PATHWAYS |
| Issue Date | Dec-2020 |
| Publisher | NANO RESEARCH |
| Abstract | Interferon (IFN) responses are central to host defense against coronavirus and other virus infections. Manganese (Mn) is capable of inducing IFN production, but its applications are limited by nonspecific distributions and neurotoxicity. Here, we exploit chemical engineering strategy to fabricate a nanodepot of manganese (nanoMn) based on Mn2+. Compared with free Mn2+, nanoMn enhances cellular uptake and persistent release of Mn2+ in a pH-sensitive manner, thus strengthening IFN response and eliciting broad-spectrum antiviral effects in vitro and in vivo. Preferentially phagocytosed by macrophages, nanoMn promotes M1 macrophage polarization and recruits monocytes into inflammatory foci, eventually augmenting antiviral immunity and ameliorating coronavirus-induced tissue damage. Besides, nanoMn can also potentiate the development of virus-specific memory T cells and host adaptive immunity through facilitating antigen presentation, suggesting its potential as a vaccine adjuvant. Pharmacokinetic and safety evaluations uncover that nanoMn treatment hardly induces neuroinflammation through limiting neuronal accumulation of manganese. Therefore, nanoMn offers a simple, safe, and robust nanoparticle-based strategy against coronavirus. |
| URI | http://hdl.handle.net/20.500.11897/608290 |
| ISSN | 1998-0124 |
| DOI | 10.1007/s12274-020-3243-5 |
| Indexed | EI SCI(E) |
| Appears in Collections: | 基础医学院 北京肿瘤医院 药学院 |
