| Title | Maternal GDM Status, Genetically Determined Blood Glucose, and Offspring Obesity Risk: An Observational Study |
| Authors | Song, Qiying Wang, Leishen Liu, Huikun Liang, Zhaoxia Chen, Yuhang Sun, Dianjianyi Li, Weiqin Leng, Junhong Yang, Xilin Cardoso, Marly Augusto Hu, Gang Qi, Lu |
| Affiliation | Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA 70118 USA Peking Univ, Sch Publ Hlth, Dept Maternal & Child Hlth, Beijing, Peoples R China Tianjin Womens & Childrens Hlth Ctr, Tianjin, Peoples R China Zhejiang Univ, Womens Hosp, Dept Obstet, Sch Med, Hangzhou, Zhejiang, Peoples R China Sichuan Univ, West China Sch Publ Hlth, Dept Publ Hlth Lab Sci, Chengdu, Sichuan, Peoples R China Tianjin Med Univ, Sch Publ Hlth, Dept Epidemiol, Tianjin, Peoples R China Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo, Brazil Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Dept Med, Boston, MA 02115 USA |
| Keywords | GESTATIONAL DIABETES-MELLITUS BODY-MASS INDEX CHILDHOOD OBESITY PREVENTION PROGRAM CHINESE WOMEN BIRTH-WEIGHT PREGNANCY ASSOCIATION ADIPOSITY TRAITS |
| Issue Date | Dec-2020 |
| Publisher | OBESITY |
| Abstract | Objective The purpose of this study was to estimate the associations of genetically determined maternal blood glucose levels with obesity-related outcomes among children from pregnancies with and without gestational diabetes mellitus (GDM). Methods A total of 1,114 mothers with (N = 560) and without (N = 554) GDM and their children were included in the present study. A maternal genetic risk score (GRS) for blood glucose was constructed on the basis of 17 single-nucleotide polymorphisms identified from a recent genome-wide association study. Results It was found that maternal GRS for blood glucose showed different associations with offspring risk of overweight and obesity, as well as adiposity measures (all P (for interaction) < 0.05). Among mothers without GDM, genetically determined maternal blood glucose levels were associated with an 89% higher risk of overweight in their children (95% CI: 42%-152% per SD increase in GRS, P = 1.40 x 10(-5)) and a 120% higher risk of obesity (44%-235%, P = 2.61 x 10(-4)) after adjustment for covariates. In addition, higher maternal GRS for blood glucose was associated with children's increased obesity-related traits (all P < 0.05). However, no significant associations were observed among children of mothers with GDM. Conclusions This study indicates that GDM status may modify the relation between genetically determined glucose levels and obesity risk among children. |
| URI | http://hdl.handle.net/20.500.11897/608159 |
| ISSN | 1930-7381 |
| DOI | 10.1002/oby.23047 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 |
