| Title | Comparing EQ-5D-3L and EQ-5D-5L performance in common cancers: suggestions for instrument choosing |
| Authors | Zhu, Juan Yan, Xin-Xin Liu, Cheng-Cheng Wang, Hong Wang, Le Cao, Su-Mei Liao, Xian-Zhen Xi, Yun-Feng Ji, Yong Lei, Lin Xiao, Hai-Fan Guan, Hai-Jing Wei, Wen-Qiang Dai, Min Chen, Wanqing Shi, Ju-Fang |
| Affiliation | Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Clin Res Ctr Canc, Natl Canc Ctr,Off Canc Screening, 17 Panjiayuan South Lane, Beijing 100021, Peoples R China Sun Yat Sen Univ, Canc Ctr, Guangzhou, Peoples R China Hunan Canc Hosp, Hunan Off Canc Control & Res, Changsha, Peoples R China Inner Mongolia Ctr Dis Control & Prevent, Hohhot, Peoples R China Chinese Acad Med Sci, Canc Hosp, Shenzhen Ctr, Shenzhen, Peoples R China Shenzhen Ctr Chron Dis Control, Shenzhen, Peoples R China Peking Univ, China Ctr Hlth Econ Res, Beijing, Peoples R China Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Clin Res Ctr Canc, Natl Canc Ctr,Canc Registry Off, Beijing, Peoples R China |
| Keywords | QUALITY-OF-LIFE PSYCHOMETRIC PROPERTIES GENERAL-POPULATION STANDARD EQ-5D VALUE SET EUROQOL VERSION 3-LEVEL |
| Issue Date | Sep-2020 |
| Publisher | QUALITY OF LIFE RESEARCH |
| Abstract | Purpose To compare the performance of three-level EuroQol five-dimensions (EQ-5D-3L) and five-level EuroQol five-dimensions (EQ-5D-5L) among common cancer patients in urban China. Methods A hospital-based cross-sectional survey was conducted in three provinces from 2016 to 2018 in urban China. Patients with breast cancer, colorectal cancer, or lung cancer were recruited to complete the EQ-5D-3L and EQ-5D-5L questionnaires. Response distribution, discriminatory power (indicator: Shannon index [H '] and Shannon evenness index [J ']), ceiling effect (the proportion of full health state), convergent validity, and health-related quality of life (HRQoL) were compared between the two instruments. Results A total of 1802 cancer patients (breast cancer: 601, colorectal cancer: 601, lung cancer: 600) were included, with the mean age of 55.6 years. The average inconsistency rate was 4.4%. Compared with EQ-5D-3L (average: H ' = 1.100,J ' = 0.696), an improved discriminatory power was observed in EQ-5D-5L (H ' = 1.473,J ' = 0.932), especially contributing to anxiety/depression dimensions. The ceiling effect was diminished in EQ-5D-5L (26.5%) in comparison with EQ-5D-3L (34.5%) (p < 0.001), mainly reflected in the pain/discomfort and anxiety/depression dimensions. The overall utility score was 0.790 (95% CI 0.778-0.801) for EQ-5D-3L and 0.803 (0.790-0.816) for EQ-5D-5L (p < 0.001). A similar pattern was also observed in the detailed cancer-specific analysis. Conclusions With greater discriminatory power, convergent validity and lower ceiling, EQ-5D-5L may be preferable to EQ-5D-3L for the assessment of HRQoL among cancer patients. However, higher utility scores derived form EQ-5D-5L may also lead to lower QALY gains than those of 3L potentially in cost-utility studies and underestimation in the burden of disease. |
| URI | http://hdl.handle.net/20.500.11897/607673 |
| ISSN | 0962-9343 |
| DOI | 10.1007/s11136-020-02636-w |
| Indexed | SCI(E) SSCI |
| Appears in Collections: | 国家发展研究院 |
