| Title | Catheter-integrated soft multilayer electronic arrays for multiplexed sensing and actuation during cardiac surgery |
| Authors | Han, Mengdi Chen, Lin Aras, Kedar Liang, Cunman Chen, Xuexian Zhao, Hangbo Li, Kan Faye, Ndeye Rokhaya Sun, Bohan Kim, Jae-Hwan Bai, Wubin Yang, Quansan Ma, Yuhang Lu, Wei Song, Enming Baek, Janice Mihyun Lee, Yujin Liu, Clifford Model, Jeffrey B. Yang, Guanjun Ghaffari, Roozbeh Huang, Yonggang Efimov, Igor R. Rogers, John A. |
| Affiliation | Northwestern Univ, Querrey Simpson Inst Bioelect, Evanston, IL 60208 USA Northwestern Univ, Dept Civil Engn, Evanston, IL 60208 USA Northwestern Univ, Dept Environm Engn, Evanston, IL 60208 USA Xi An Jiao Tong Univ, Sch Mat Sci & Engn, State Key Lab Mech Behav Mat, Xian, Peoples R China George Washington Univ, Dept Biomed Engn, Washington, DC 20052 USA Tianjin Univ, Key Lab Mech Theory & Equipment Design, Minist Educ, Sch Mech Engn, Tianjin, Peoples R China Peking Univ, Acad Adv Interdisciplinary Studies, Beijing, Peoples R China Univ Southern Calif, Dept Aerosp & Mech Engn, Los Angeles, CA 90007 USA Northwestern Univ, Dept Mech Engn, Evanston, IL 60208 USA Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA Univ Cambridge, Dept Engn, Cambridge, England Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA Univ Illinois Urbana Champaign Urbana, Frederick Seitz Mat Res Lab, Champaign, IL 61820 USA Univ Illinois Urbana Champaign Urbana, Dept Elect & Comp Engn, Champaign, IL USA Tianjin Univ, Sch Chem Engn & Technol, Tianjin, Peoples R China Univ Illinois Urbana Champaign Urbana, Dept Chem, Champaign, IL USA Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA Northwestern Univ, Dept Surg, Feinberg Sch Med, Chicago, IL 60611 USA Northwestern Univ, Dept Chem, Evanston, IL 60208 USA Northwestern Univ, Dept Elect Engn & Comp Sci, Evanston, IL 60208 USA |
| Keywords | BALLOON CATHETERS ABLATION DELIVERY SENSOR |
| Issue Date | Sep-2020 |
| Publisher | NATURE BIOMEDICAL ENGINEERING |
| Abstract | Soft multilayer electronic arrays on endocardial balloon catheters allow for multiplexed high-density spatiotemporal sensing and actuation, as shown in perfused ex vivo hearts. The rigidity and relatively primitive modes of operation of catheters equipped with sensing or actuation elements impede their conformal contact with soft-tissue surfaces, limit the scope of their uses, lengthen surgical times and increase the need for advanced surgical skills. Here, we report materials, device designs and fabrication approaches for integrating advanced electronic functionality with catheters for minimally invasive forms of cardiac surgery. By using multiphysics modelling, plastic heart models and Langendorff animal and human hearts, we show that soft electronic arrays in multilayer configurations on endocardial balloon catheters can establish conformal contact with curved tissue surfaces, support high-density spatiotemporal mapping of temperature, pressure and electrophysiological parameters and allow for programmable electrical stimulation, radiofrequency ablation and irreversible electroporation. Integrating multimodal and multiplexing capabilities into minimally invasive surgical instruments may improve surgical performance and patient outcomes. |
| URI | http://hdl.handle.net/20.500.11897/607637 |
| ISSN | 2157-846X |
| DOI | 10.1038/s41551-020-00604-w |
| Indexed | SCI(E) |
| Appears in Collections: | 前沿交叉学科研究院 |
