| Title | Effect of hydroxychloroquine on preeclampsia in lupus pregnancies: a propensity score-matched analysis and meta-analysis |
| Authors | Liu, Yingnan Zhang, Yueyi Wei, Yumei Yang, Huixia |
| Affiliation | Peking Univ, Hosp 1, Dept Obstet & Gynecol, 1 Xi Anmen St, Beijing, Peoples R China Beijing Key Lab Maternal Fetal Med Gestat Diabet, Beijing, Peoples R China Chinese Acad Med Sci, Dept Internal Med, Beijing, Peoples R China Peking Union Med Coll, Beijing, Peoples R China |
| Keywords | INTRAUTERINE GROWTH RESTRICTION ERYTHEMATOSUS WOMEN HYPERTENSION |
| Issue Date | Sep-2020 |
| Publisher | ARCHIVES OF GYNECOLOGY AND OBSTETRICS |
| Abstract | Background Hydroxychloroquine (HCQ) is the primary medication in the treatment of pregnancy with systemic lupus erythematosus (SLE) for its efficacy and safety. However, the effect of HCQ on preeclampsia prevention remains controversial. Objective This study aimed to investigate whether HCQ has an effect on preeclampsia prevention and other pregnancy outcomes among lupus pregnancy. Methods We conducted a retrospective cohort study of 119 pregnant women with SLE. After the propensity score matching of baseline characteristics, the population was divided into the HCQ treatment group and HCQ nontreatment group. Then, we compared the preeclampsia and other pregnancy outcomes between HCQ treatment and nontreatment groups. Furthermore, we combined our data and previous studies for a meta-analysis. Results In our data, HCQ did not increase the risk of premature rupture of membranes, bleeding during pregnancy, preeclampsia, intrauterine distress, gestational age at delivery, preterm birth, and postpartum hemorrhage. There was no significant association between HCQ treatment and preeclampsia prevention. Besides, the meta-analysis showed a similar result that HCQ did not significantly decrease the rate of preeclampsia (RR = 0.61, 95%CI = 0.34-1.11). Conclusion This study found that HCQ treatment was safe, but did not significantly reduce preeclampsia among lupus pregnancies. |
| URI | http://hdl.handle.net/20.500.11897/607593 |
| ISSN | 0932-0067 |
| DOI | 10.1007/s00404-020-05762-5 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 |
