| Title | Disordered serum erythroferrone and hepcidin levels as indicators of the spontaneous abortion occurrence during early pregnancy in humans |
| Authors | Wei, Shuting Liu, Wei Qi, Yu Guo, Yifan Zhang, Shuping Wang, Li Zhuang, Taifeng Zhang, Na Liu, Sijin |
| Affiliation | Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing, Peoples R China Shanxi Univ, Coll Environm & Resource, Res Ctr Environm & Hlth, Taiyuan, Peoples R China Univ Chinese Acad Sci, Beijing, Peoples R China Peking Univ, Dept Clin Lab, Peoples Hosp, Beijing, Peoples R China Shandong First Med Univ &, Shandong Med Biotechnol Ctr, Jinan, Peoples R China Shandong Acad Med Sci, Jinan, Peoples R China Capital Med Univ, Beijing Obstet & Gynecol Hosp, Dept Ultrasound, 251 Yaojiayuan Rd, Beijing 100026, Peoples R China Capital Med Univ, Beijing Obstet & Gynecol Hosp, Dept Pediat, Beijing, Peoples R China |
| Keywords | IRON-DEFICIENCY ANEMIA FERRITIN MISCARRIAGE HOMEOSTASIS METABOLISM |
| Issue Date | Aug-2020 |
| Publisher | BRITISH JOURNAL OF HAEMATOLOGY |
| Abstract | Spontaneous abortion is a common, detrimental outcome of pregnancy, and can be induced by a variety of factors, including pathophysiological conditions and socioeconomic circumstances. Despite numerous studies examining the aetiology of spontaneous abortion, there is limited understanding of the disordered iron transportation between mother and fetus through the placenta. Recently, erythroferrone (ERFE) was recognized as a novel negative regulator of hepcidin that can elevate nutritional iron absorption and macrophagic iron egress for enhanced erythropoiesis. However, its diagnostic significance in different disease conditions associated with iron remains poorly understood. In the current study, we discovered disordered maternal iron homeostasis in women who had spontaneous abortions during early pregnancy, as characterized by increased serum iron and hepcidin levels, and conversely, reduced serum ERFE levels, compared to healthy control individuals and women with normal pregnancy. Comprehensive statistical analyses revealed the correlation between different variables and pregnancy status, signifying the pronounced diagnostic value of an increased ratio of serum hepcidin and ERFE (HE ratio) in recognizing adverse pregnancy status. In contrast to previous non-selective discrete surrogates, such as iron, hepcidin and ferritin, the HE ratio may otherwise stand for a novel and more representative hallmark for early spontaneous abortion. |
| URI | http://hdl.handle.net/20.500.11897/607558 |
| ISSN | 0007-1048 |
| DOI | 10.1111/bjh.17049 |
| Indexed | SCI(E) |
| Appears in Collections: | 人民医院 |
